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Method for extracting active substances from Chinese traditional compound medicine

A technology for active substances and compound recipes, applied in the field of extracting active substances from traditional Chinese medicine compounds, can solve the problems of easy loss of heat-labile volatile components, loss of heat-sensitive components, and difficulty in product processing, and achieves no need for solvent recovery, enhanced dissolution, and high production efficiency. Effect

Inactive Publication Date: 2011-07-13
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the extraction of active substances of Chinese herbal medicines is mainly carried out by decocting or organic solvent extraction. Most of the active ingredients in traditional Chinese medicine can be decocted by decocting in water, but there are many impurities in the decocted liquid, and the purity is low, and the volatile components that are not heat-resistant are easy to extract. loss
Due to the toxicity of the solvent, organic solvent extraction often uses reflux devices and continuous extraction devices. Reflux extraction has great limitations in production, and continuous extraction requires 6 to 8 hours at high temperature. In addition to taking too long, it will also affect heat sensitivity. ingredients cause loss
At the same time, both of these two extraction methods have solvent residues, which cause difficulties for subsequent product processing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Take lotus leaf, hawthorn, cassia seed, and Alisma compound, grind them through a sieve with an aperture of 0.3mm, take 60g of the sifted powder, and treat with 50% microwave / 50% light wave, the output power is 600-800W, and the total processing time is 2min. Then placed in 1LCO 2 In the extraction kettle of supercritical extraction equipment, seal and stopper, use supercritical CO 2 The fluid is the extraction agent, the extraction pressure is set within the range of 28Mpa-30MPa, the extraction temperature is within the range of 35°C-60°C, 100mL-200mL of entrainer ethanol is added, the pressure of the separation tank I is set between 7Mpa-10MPa, and the temperature is 40 Between ℃-60℃, separation kettle II 4Mpa-7MPa, temperature 20-40℃, after 1-3h, 2.51g of extract was obtained from separation kettle I, and recovered alcohol was obtained in separation kettle II. After testing, the extract contains 5% alkaloids, 10% total triterpenes, 3% total anthraquinones, and 3.4% ...

Embodiment 2

[0014] Take lotus leaf, hawthorn, cassia seed, and Alisma compound and grind them, pass through a sieve with an aperture of 0.2mm, take 60g of the sifted powder, and treat with 100% microwave at an output power of 600-800W, and the total processing time is 2min. Then placed in 1L CO 2 In the extraction kettle of supercritical extraction equipment, seal and stopper, use supercritical CO 2 The fluid is the extraction agent, the extraction pressure is set within the range of 28Mpa-30MPa, the extraction temperature is within the range of 35°C-60°C, 100mL-200mL of entrainer ethanol is added, the pressure of the separation tank I is set between 7Mpa-10MPa, and the temperature is 40 Between ℃-60℃, separation kettle II 4Mpa-7MPa, temperature 20-40℃, after 1-3h, 2.49g of extract was obtained from separation kettle I, and recovered alcohol was obtained in separation kettle II. After testing, the extract contains 4.8% alkaloids, 9.8% total triterpenes, 3% total anthraquinones, and 3.3% ...

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Abstract

The invention relates to a method for extracting active substances from Chinese traditional compound medicine. The method comprises the following steps: (1), the Chinese traditional compound medicine is dried and crushed with grain size of 0.15 mm-0.45 mm; (2), the crushed compound medicine powder is put in a vessel and processed for 1-10 min with 100 percent of microwave or in a combine manner of microwave and light wave; and (3), the processed compound medicine powder is put in a supercritical extraction apparatus for a double-separation vessel, wherein supercritical CO2 fluid is taken as the extracting agent, the extracting pressure is ranged from 28 MPa to 35 MPa, and the extracting temperature is ranged from 35 DEG C to 60 DEG C. The invention increases the dissolution rate of the active substances in the follow-up supercritical process, enlarges the application range of the CO2 supercritical extraction through combining the microwave / light wave dry preprocessing with the CO2 supercritical extraction, has short entire process flow period, high production efficiency, less solvent consumption, small equipment contamination and no solvent recovery, and can be directly used for processing medicines or health care products.

Description

technical field [0001] The invention relates to an extraction method, in particular to a method for extracting active substances of traditional Chinese medicine compound. Background technique [0002] There have been many years of research and practice in my country on the extraction and application of compound Chinese medicines. At present, the extraction of active substances of Chinese herbal medicines is mainly carried out by decocting or organic solvent extraction. Most of the active ingredients in traditional Chinese medicine can be decocted by decocting in water, but there are many impurities in the decocted liquid, and the purity is low, and the volatile components that are not heat-resistant are easy to extract. loss. Due to the toxicity of the solvent, organic solvent extraction often uses reflux devices and continuous extraction devices. Reflux extraction has great limitations in production, and continuous extraction requires 6 to 8 hours at high temperature. In a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/00A61K36/884B01D11/02
Inventor 邓泽元甘露菁李静范亚苇刘蓉
Owner NANCHANG UNIV