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Lacrimal passage stopper and preparation method thereof

A lacrimal duct and polyvinyl alcohol technology, which is applied in the field of medical equipment, can solve the problems that imported lacrimal duct plugs are expensive, unaffordable, and cannot be widely used, and achieve the effects of good safety, simple manufacturing process, and low cost

Inactive Publication Date: 2013-01-02
SHANGHAI TENTH PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the specific process and patent protection, the price of imported tear duct plugs is expensive, which is unbearable for the income level of the Chinese population, and cannot be widely used, and cannot fundamentally achieve the purpose of improving the symptoms and signs of dry eye syndrome in the population
At present, no related lacrimal duct plugs have been developed and developed in China to treat dry eye and related diseases. Therefore, it is necessary to independently develop a lacrimal duct plugs suitable for my country's national conditions on the basis of referring to foreign advanced technologies, and finally improve the condition of the population. Symptoms and Signs of Dry Eye

Method used

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  • Lacrimal passage stopper and preparation method thereof
  • Lacrimal passage stopper and preparation method thereof
  • Lacrimal passage stopper and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Dissolve polyvinyl alcohol and polyvinylpyrrolidone in 80°C water at a ratio of 1:1, cool to 70°C, and pour into the mold;

[0028] (2) Bake in an oven at 60°C for 20 minutes, cool overnight, and demould;

[0029] (3) Soak in 50% alcohol for 2h to carry out purification treatment;

[0030] (4) Soak in distilled water for 24 hours;

[0031] (5) Put it into a constant temperature drying oven and bake at 60°C for 1 hour; and

[0032] (6) Put it into a sterile glass bottle.

[0033] Using two kinds of moulds, two sizes of lacrimal plugs are made. One of them has a length of 10±1mm and a radius of 0.3±0.1mm in a dry state; the other has a length of 8±2mm and a radius of 0.5±0.1mm in a dry state.

[0034] The lacrimal plugs of the second size were soaked in distilled water at room temperature. After 24 hours, the length was 11 ± 0.2 mm and the radius was 2.2 ± 0.3 mm.

[0035] The lacrimal plug is soaked at 38°C for a long time, and it will be completely degraded in ...

Embodiment 2

[0037] Except that polyvinyl alcohol and polyvinylpyrrolidone were dissolved in 90°C water at a ratio of 1:3, the rest was the same as in Example 1, and the lacrimal duct plug was also made.

Embodiment 3

[0039] Except that polyvinyl alcohol and polyvinylpyrrolidone were dissolved in 85°C water at a ratio of 3:1, the rest was the same as in Example 1, and a lacrimal plug was also made.

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Abstract

The invention provides a lacrimal passage stopper which is a bar-shaped object prepared from polyvinyl alcohol and polyvinylpyrrolidone according to the weight ratio of 1:3-3:1, wherein the molecular weight of the polyvinyl alcohol is 20000-200000, and the molecular weight of the polyvinylpyrrolidone is 8000-200000. The preparation method of the lacrimal passage stopper comprises the following steps: dissolving the raw materials into hot water with the temperature of more than 80 DEG C, cooling to the temperature of 70 DEG C and filling into a mould; baking for 20min in a baking oven at the temperature of 60 DEG C; and cooling over night, stripping and molding. Toxicity experiments and animal model experiments prove that the lacrimal passage stopper has safety, favorable biologic compatibility and clinical practicability and can improve xeroma symptoms obviously. The invention has simple preparation process and lower cost, conforms to the economic level of China and is beneficial to the future development and application.

Description

technical field [0001] The invention belongs to the field of medical equipment, in particular, the invention relates to ophthalmic treatment equipment, and more specifically relates to a lacrimal duct plug. Background technique [0002] Dry eye syndrome is an ocular surface disease characterized by tear film instability and ocular surface tissue damage caused by abnormal tear quality and quantity, or dynamics, accompanied by ocular symptoms. With the change of people's lifestyle and the popularization of computers, the prevalence of dry eye is increasing year by year, and the proportion of outpatient visits to ophthalmology clinics is increasing. According to incomplete statistics, the prevalence of dry eye in my country is between 7% and 10%. [0003] The traditional dry eye treatment method is mainly based on artificial tear drops, and corticosteroids, immunosuppressants and lacrimal duct plugs are also used for the treatment of dry eye. Lacrimal duct plug therapy combin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61F9/007
Inventor 盛敏杰赵菲郑一仁
Owner SHANGHAI TENTH PEOPLES HOSPITAL