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Composition for treating arrhythmia and preparation method thereof

A composition and arrhythmia technology, which is applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as inconvenient use, poor quality controllability, and large prescriptions

Inactive Publication Date: 2010-04-21
华润医药商业集团国际贸易有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the chemical medicines for the treatment of this disease have a certain curative effect, but the side effects are large; the traditional Chinese medicine prescriptions for the treatment of this disease are safe and effective, but they often have huge prescriptions, backward dosage forms, poor quality controllability, and are inconvenient to use

Method used

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  • Composition for treating arrhythmia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Prescription: 473g ginseng, 2365g Ophiopogon japonicus, 788g lotus seed heart, 1577g notoginseng, 631g Zhiguanbaifu (equivalent to 3:15:5:10:4).

[0061] Preparation method: Take ginseng, Panax notoginseng and Ophiopogon japonicus 3 medicinal materials, pulverize, mix evenly, add 80% ethanol with a volume 8 times the total weight, heat and reflux twice, each time for 1.5 hours, combine the reflux liquid, filter, reduce Recover the ethanol by pressure to the end, add an equal volume of water-saturated n-butanol to extract 5 times, take the n-butanol layer, combine, recover the solvent under reduced pressure and concentrate, vacuum dry, pulverize, and obtain crude saponins of ginseng, notoginseng, and radix radix, and set aside ; Take lotus seed heart and Zhiguanbaifu 2 medicinal materials, add 10 times the total weight of the HCL aqueous solution with a volume of pH=3 and decoct 2 times, 2 hours each time, combine the medicinal liquids, filter, and adjust the filtrate to ...

Embodiment 2

[0069] Prescription: ginseng 1587g, Ophiopogon japonicus 794g, lotus seed heart 317g, notoginseng 476g, Zhiguanbaifu 159g (equivalent to 10:5:2:3:1).

[0070] Preparation method: with embodiment 1.

[0071] Usage: 3 times a day, 2 capsules each time

[0072] Pharmacological test: with reference to the method of Test Example 3.4, the dosage of the composition of this embodiment is 1.6g crude drug / kg, and the test results are shown in the following table:

[0073] Table 6 on the effect of aconitine-induced arrhythmia in rats (n=12)

[0074] group

[0075] The results show that compared with the model group, the composition obtained in this embodiment can significantly delay the occurrence time of aconitine-induced arrhythmia in rats (P<0.05), and improve the 1-hour survival rate of aconitine-induced arrhythmia rats ( P<0.05).

Embodiment 3

[0077] Prescription: ginseng 1471g, Ophiopogon japonicus 735g, lotus seed heart 735g, Sanqi 1471g, Zhiguanbaifu 588g (equivalent to 10:5:5:10:4).

[0078] Preparation method: with embodiment 1.

[0079] Usage: 3 times a day, 2 capsules each time

[0080] Pharmacological test: with reference to the method of Test Example 3.4, the dosage of the composition of this embodiment is 2.4g crude drug / kg, and the test results are shown in the following table:

[0081] Table 7 on the effect of aconitine-induced arrhythmia in rats (n=12)

[0082] group

[0083] group

[0084] The results show that compared with the model group, the composition obtained in this embodiment can significantly delay the occurrence time of aconitine-induced arrhythmia in rats (P<0.05), and improve the 1-hour survival rate of aconitine-induced arrhythmia rats ( P<0.05).

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Abstract

The invention relates to a composition for treating arrhythmia. The composition is prepared from the following raw materials in part by weight: 3 to 10 parts of ginseng, 5 to 15 parts of dwarf lilyturf tuber, 2 to 5 parts of lotus plumule, 3 to 10 parts of sanchi and 1 to 4 parts of processed Korean aconite root. The composition has the advantages of simple formula and exact curative effect of treating the arrhythmia. The invention also relates to a preparation method for the composition, which comprises the following steps of: crushing and evenly mixing the ginseng, the sanchi and the dwarf lilyturf tuber; adding ethanol for reflux; adding water saturated normal butanol with the same volume to extract for five times; taking a normal butanol layer to obtain crude saponin for later use; taking the lotus plumule and the processed Korean aconite root, and adding aqueous solution of HCL of which the pH is equal to 3 for decoction; regulating the solution to be neutral with NaOH; concentrating the solution into thick paste; and adding the crude saponin and an adjuvant to prepare a pharmaceutically acceptable preparation. The preparation method can ensure controllable quality and convenient use of the composition.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a composition composed of traditional Chinese medicines and a preparation method thereof. Background technique [0002] Arrhythmia (Cardiac Arrhythmia) is a clinical common disease, frequently-occurring disease, severe arrhythmia is one of the final causes of death in patients with myocardial hypertrophy, myocardial ischemia, myocardial infarction and heart failure. Arrhythmia refers to abnormalities in the frequency, rhythm, origin, conduction velocity, and sequence of cardiac impulses. Common arrhythmias include sinus tachycardia, sinus bradycardia, sinus arrhythmia, premature beats, paroxysmal tachycardia, atrial fibrillation, and atrioventricular block. The main clinical manifestations are palpitations, palpitations, and abnormal pulse conditions, and dizziness, dizziness, chest pain, shortness of breath, sweating, cold limbs, or collapse can b...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61P9/06
Inventor 王琳范淦彬
Owner 华润医药商业集团国际贸易有限公司