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Oridonin solid dispersion preparation

A technology of oridonin and solid dispersion, applied in the field of biomedicine, can solve the problems of less gastrointestinal absorption, incomplete dissolution, slow dissolution, etc., and achieve high bioavailability, good dissolution in vitro, and high dissolution rate Effect

Inactive Publication Date: 2010-05-05
佟丽 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ordinary preparations (such as ordinary tablets) of drugs of this nature dissolve very slowly, incompletely, and have little gastrointestinal absorption, resulting in more drug waste and inability to give full play to the therapeutic effect of drugs.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1, Rubescensin A Solid Dispersion No. 1

[0028] Take 5g Rubescensin A and crush it through a 100-mesh sieve, mix it with 50g polyethylene glycol 4000, heat together, stir, and Rubescensin A is basically dissolved, and quickly pour it on a cold stainless steel plate to cool, and it becomes a white waxy solid. It is the polyethylene glycol solid dispersion of oridonin. The solid dispersion is rapidly soluble in water.

Embodiment 2

[0029] Embodiment 2, Rubescensin A solid dispersion No. 2

[0030] Take 5g Rubescensin A and dissolve it in hot 100ml ethanol, mix it with 300ml ethanol solution containing 10% polyvinylpyrrolidone K30, and then evaporate the ethanol under reduced pressure in a rotary evaporator to obtain a white powdery solid, which is winter A polyvinylpyrrolidone solid dispersion of lobeidin. The solid dispersion is rapidly soluble in water.

Embodiment 3

[0031] Embodiment 3, Rubescensin A solid dispersion No. 3

[0032]Get 5g Rubescensin A and dissolve it in 50ml ethyl acetate, add 25g poloxamer P188 to dissolve, and then evaporate the acetone under reduced pressure in a rotary evaporator to obtain a white waxy solid, which is the product of Rubescensin A. Poloxamer solid dispersion. The solid dispersion is rapidly soluble in water.

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PUM

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Abstract

The invention discloses an oridonin solid dispersion preparation and a preparation method thereof. The solid dispersion can obviously increase the digestion of oridonin in water and is beneficial to absorption by taking orally. The preparation form of the oridonin solid dispersion preparation can be tablets, capsules, granules, dry-mixing suspensions and pills.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a solid dispersion preparation of oridonin A. Background technique [0002] Oridonin A is an alkene diterpene extracted from Oridonin grass. Donglingcao, also known as Binglingcao, has the effects of clearing heat, detoxifying, reducing inflammation and relieving pain. It is produced in Henan, Hebei, Shanxi, Sichuan and other places in my country. It is also a kind of herbal medicine for folk treatment of esophageal cancer and gastric cancer. In 1991, the Ministry of Health of my country approved the use of the dried leaves and above-ground parts of Donglingcao as Chinese herbal medicines, which were included in the standards of Chinese herbal medicines issued by the Ministry. Since the 1970s, my country has begun to study the chemical components, pharmacological effects and clinical applications of Rubescens, extracting Rubescensin from it (Liu Chenjiang, Zhao Zhihong. Research progr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/16A61K9/20A61K9/48A61K31/352A61K47/34A61K47/38A61P35/00A61K47/10A61K47/32
Inventor 佟丽常菁
Owner 佟丽