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Method for preparing 5-hydroxymethyl furfural from glucose by coupling and catalyzing with isomerase/diluted hydrochloric acid

A technology for hydroxymethyl furfural and glucose, which is applied in the field of isomerase/dilute hydrochloric acid coupled catalysis to prepare 5-hydroxymethyl furfural from glucose, can solve problems such as difficult industrial application, achieve wide application, reduce operating costs, and be simple to operate Effect

Inactive Publication Date: 2012-01-11
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported that the ionic liquid reaction system is used to catalyze glucose and cellulose to prepare 5-hydroxymethylfurfural, but the process is difficult to apply industrially due to the use of expensive ionic liquids

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Weigh 100 g of anhydrous glucose and prepare a 50 mg / mL solution, add 105 g of sodium tetraborate (NaB 2 o 7 10H 2 O) and 5g magnesium sulfate (MgSO 4 ·7H 2 O) placed in a constant temperature water bath with a temperature of 70° C. and a rotation speed of 150 rpm. After the temperature was stabilized, 50 g of immobilized glucose isomerase was added to react for 8 hours. After the reaction, 49.5 g of immobilized glucose isomerase was recovered by suction filtration. The resulting filtrate containing glucose and fructose was analyzed and detected by high-performance liquid chromatography (HPLC), and the glucose isomerization rate reached 87.8%.

[0017] Collect 2000 mL of filtrate for acid dehydration reaction, add 45 mL of hydrochloric acid with a mass concentration of 36%, 100 g of sodium chloride and 3000 mL of n-butanol, and react in an oil bath at 190 °C for 50 min. After the reaction, the resulting solution containing 5-hydroxymethylfurfural was cooled to room...

Embodiment 2

[0019] Weigh 100 g of anhydrous glucose to prepare a 0.5 g / mL solution, add 105 g of sodium tetraborate (NaB 2 o 7 10H 2 O) and 0.5g magnesium sulfate (MgSO 4 ·7H 2 O) placed in a constant temperature water bath with a temperature of 70° C. and a rotation speed of 150 rpm. After the temperature stabilized, 50 g of immobilized glucose isomerase was added to react for 12 hours, and the immobilized glucose isomerase was recovered by suction filtration after the reaction. The resulting filtrate containing glucose and fructose was analyzed and detected by high-performance liquid chromatography (HPLC), and the glucose isomerization rate reached 86.4%.

[0020] Collect 200mL of filtrate for acid dehydration reaction, add 8.5mL of hydrochloric acid with a mass concentration of 36%, 10g of sodium chloride and 300mL of n-butanol, and react in an oil bath at 190°C for 40min. After the reaction, the resulting solution containing 5-hydroxymethylfurfural was cooled to room temperature ...

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PUM

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Abstract

The invention discloses a method for preparing 5-hydroxymethyl furfural from glucose by coupling and catalyzing with isomerase / diluted hydrochloric acid, comprising the following steps: adding sodium borate and immobilized glucose isomerase to glucose solution to obtain the mixed solution of glucose and fructose through reaction; filtering and recovering the immobilized glucose isomerase, and adding hydrochloric acid, sodium chloride and butanol to obtained filtrate to carry out acid catalysis to synthesize the 5-hydroxymethyl furfural; cooling the solution of aqueous phase and butanol phase to room temperature, and separating the aqueous phase from the butanol phase by decompressing and evaporating the aqueous phase or carrying out ion exchanging for the aqueous phase or separating the aqueous phase with a membrane to recover the inorganic salts comprising sodium borate and sodium chloride. The method can efficiently synthesize the 5-hydroxymethyl furfural by transforming the glucosein a conventional system and can recover and utilize the glucose isomerase and the inorganic salts. Compared with the prior method, the method is easy to operate and is more economically feasible andpractical.

Description

technical field [0001] The invention relates to a method for preparing 5-hydroxymethylfurfural from glucose through coupling catalysis of isomerase / dilute hydrochloric acid, which belongs to the preparation technology of 5-hydroxymethylfurfural. Background technique [0002] Synthesizing clean fuels and bio-based chemicals from biomass resources to replace petrochemicals has become an inevitable trend for sustainable economic and social development. Lignocellulose (the most abundant biomass resource on earth) is saccharified to produce soluble sugars such as glucose, and then based on biological / chemical conversion technology, fuel ethanol and sugar-based chemicals can be synthesized, thereby gradually establishing a circular green economic model, which is of great importance to the solution The current energy crisis, resource shortage, environmental pollution and other issues are of great significance. [0003] 5-Hydroxymethylfurfural is an important platform chemical that...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P17/04C07D307/46
Inventor 齐崴黄仁亮苏荣欣何志敏
Owner TIANJIN UNIV