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Milbemycin or milbemycin oxime sustained-release injection for animals and preparation method

A technology of mebemycin oxime and mebemycin, which is applied in the field of veterinary sustained-release injections and its preparation, can solve the problems of manpower consumption, repeated stress of sick animals, unfavorable treatment of animal diseases, etc., and reduce the Reduce labor intensity, reduce stress response, and improve the effect of repelling insects

Active Publication Date: 2010-07-14
BEIJING DABEINONG ANIMAL HEALTH TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Mebemycin (oxime) can achieve the purpose of killing and expelling parasites in a short period of time, but due to the rapid excretion, multiple administrations are required to achieve a better anthelmintic effect and the interval between administrations Not long, which not only consumes a lot of manpower but also causes multiple stresses to sick animals, which is not conducive to the treatment of animal diseases and does not meet the requirements of animal welfare

Method used

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  • Milbemycin or milbemycin oxime sustained-release injection for animals and preparation method
  • Milbemycin or milbemycin oxime sustained-release injection for animals and preparation method
  • Milbemycin or milbemycin oxime sustained-release injection for animals and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 400ml of soybean oil for injection, 200g of n-butanol, and mix evenly; add 20g of cetyl alcohol and 10.0g of mebemycin in sequence, and stir to dissolve; dilute to 1000ml with soybean oil for injection, filter; potting, 100 ℃ sterilization for 30 minutes, that is.

Embodiment 2

[0026] Take 400ml of sesame oil for injection and 100g of propylene glycol, and mix them evenly; add 2.0g of myristyl alcohol, 1.0g of albendazole, and 1.0g of mebemycin in sequence, stir and dissolve; dilute to 1000ml with sesame oil for injection, and filter; Potting and sterilizing at 100°C for 30 minutes, ready to serve.

Embodiment 3

[0028] Take 300ml of camellia oil for injection and 500g of glycerin formal, and mix them evenly; add 100g of stearyl alcohol, 5.0g of fenbendazole, and 5.0g of mebemycin in sequence, and stir to dissolve; dilute to 1000ml with camellia oil for injection , filtered; potted, sterilized at 100 ° C for 30 minutes, that is.

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Abstract

The invention relates to a milbemycin or milbemycin oxime sustained-release injection for animals and a preparation method. The sustained-release injection for animals takes milbemycin or milbemycin oxime as main components, takes a vegetable oil as a main solvent, is added with higher fatty alcohol or a high molecular compound to play the sustained-release role to prepare the sustained-release injection, and is also added with albendazole and fenbendazole to prepare a compound injection. Clinical trials confirm that the sustained-release injection of the invention obviously prolongs the anthelmintic time of drugs and improves anthelmintic effect, and one-time subcutaneous injection can maintain the efficacy of the drugs for more than 3 months. The sustained-release injection for animals can reduce the anthelmintic labor intensity for the animals, reduces the stress response of the animals, and provides a safe, efficient, long-lasting broad-spectrum anthelmintic pharmaceutical preparation for veterinary clinic.

Description

technical field [0001] The invention relates to a veterinary slow-release injection of mebemycin or mebemycin oxime and a preparation method thereof, belonging to the technical field of veterinary preparations. Background technique [0002] Milbemycin (milbemycin) is a macrolide antiparasitic drug isolated from the fermentation product of Streptomyces hygroscopicus and Streptomyces cyaneogriseus by scientists from Japan Sankyo Company in 1975. Cyclic ester antiparasitic drugs are deglycosylated compounds of abamectin. Milbemycin oxime (milbemycin oxime) is an oxime derivative of mibemycin A3 and A4, wherein milbemycin A4 oxime must not be less than 80%, and A3 oxime must not exceed 20%. [0003] The anti-parasitic mechanism of mebemycin (oxime) is basically the same as that of abamectin, both of which stimulate the ion channel of γ-aminobutyric acid (GABA), affect the nerve conduction of the parasite, and then exert its drug effect. Mebemycin (oxime) is effective against t...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/365A61K47/44A61P33/00
Inventor 杨秀玉田玲刘澜莫云
Owner BEIJING DABEINONG ANIMAL HEALTH TECH
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