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Gel-forming composition

A technology of composition and gel, which is applied in the direction of drug combination, drug delivery, and medical preparations of non-active ingredients, etc. It can solve the problems of drug stability reduction, difficulty in realization, and difficulty in aseptic processing, etc.

Inactive Publication Date: 2010-07-28
LINTEC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the jelly-like semi-solid preparation reduces the stability of the medicine (especially the medicine that is easily hydrolyzed) because it contains a large amount of water, and it is difficult to aseptically handle it during preparation and preservation, because there are problems in packaging costs, so its It is difficult to achieve

Method used

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  • Gel-forming composition
  • Gel-forming composition
  • Gel-forming composition

Examples

Experimental program
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Effect test

preparation example 1

[0109] [Preparation Example 1] Preparation of oral administration preparation and oral administration preparation holder

[0110] (1) Preparation of stomach-soluble preparations and their holders

[0111] In order to form a water-swellable gel-forming layer, liquid A was prepared with the composition shown in Table 1 below. In other words, measure 45 g of purified water, slowly add 10.5 g of polyvinyl alcohol (ゴセセノ一ルEG 05T (Nippon Synthetic Chemical)) to it while stirring, and heat it at 70°C while stirring for about 1 hour to make it complete Dissolve. Similarly, measure 40 g of purified water, and slowly add 4.05 g of polyacrylic acid (Junron PW-111 (Japan Pure Chemical Industries)) to it while stirring, and stir for about 30 minutes to completely dissolve the two solutions. After fully stirring the two solutions, add chlorination Calcium 0.45g, stir for 5 minutes. In addition, calcium ions are generated by ionization of calcium chloride to crosslink polyacrylic acid, the cros...

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Abstract

With an object of providing an orally administered agent (in particular a film-shaped orally administered agent) with which the ease and safety of taking the agent are improved, to attain this object, in an orally administered agent 1b having one drug-containing layer 11 and two water-swellable gel-forming layers 12, the water-swellable gel-forming layers 12 are provided, either directly or via intermediate layers, on the both faces of the drug-containing layer 11.

Description

[0001] This application is a divisional application for a patent application whose application date is April 19, 2002, application number is 02801373.5, and the invention-creation title is "Oral Administration Preparation and Oral Administration Preparation Retainer". Technical field [0002] The present invention relates to an oral administration preparation and an oral administration preparation holder. Background technique [0003] Orally administered preparations may cause discomfort caused by the bitterness or astringency of the drug, vomiting, vomiting, refusal to take the drug, etc., which may result in low compliance with the drug. Therefore, various formulations for oral administration are being developed. [0004] As a general dosage form of oral administration preparations, solid preparations such as tablets or capsules are used. However, because these solid preparations have difficulty in swallowing directly, they usually have to be taken with a large amount of water. S...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/32A61K47/38A61K9/00A61K9/20
CPCA61K9/0053A61K9/7007A61P1/04A61K9/00
Inventor 野上英志
Owner LINTEC CORP