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Gel-forming composition

A composition and gel technology, which is applied in the direction of drug combination, drug delivery, medical preparations of non-active ingredients, etc., can solve the problems of difficult aseptic processing, decreased drug stability, and difficulties in realization, etc.

Inactive Publication Date: 2013-06-05
LINTEC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the jelly-like semi-solid preparation reduces the stability of the medicine (especially the medicine that is easily hydrolyzed) because it contains a large amount of water, and it is difficult to aseptically handle it during preparation and preservation, because there are problems in packaging costs, so its It is difficult to achieve

Method used

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  • Gel-forming composition
  • Gel-forming composition
  • Gel-forming composition

Examples

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Effect test

preparation example 1

[0109] [Preparation Example 1] Preparation of Oral Administration Preparation and Oral Administration Preparation Holder

[0110] (1) Preparation of gastric soluble preparation and its support body

[0111] In order to form a water-swellable gel-forming layer, liquid A was prepared with the composition shown in Table 1 below. That is, 45 g of purified water was measured, and 10.5 g of polyvinyl alcohol (Goosenol EG 05T (Nippon Gosei Chemical)) was slowly added thereto while stirring, and heated at 70° C. while stirring for about 1 hour to make it completely dissolve. Similarly, measure 40 g of purified water, slowly add 4.05 g of polyacrylic acid (Junlon PW-111 (Nippon Junyaku)) while stirring, and stir for about 30 minutes to completely dissolve the two solutions. Calcium 0.45g, and stirred for another 5 minutes. In addition, calcium ions are generated by ionization of calcium chloride to cross-link polyacrylic acid, the cross-linked polyacrylic acid functions as a water-s...

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Abstract

With an object of providing an orally administered agent (in particular a film-shaped orally administered agent) with which the ease and safety of taking the agent are improved, to attain this object, in an orally administered agent 1b having one drug-containing layer 11 and two water-swellable gel-forming layers 12, the water-swellable gel-forming layers 12 are provided, either directly or via intermediate layers, on the both faces of the drug-containing layer 11.

Description

[0001] This application is a divisional application of a patent application with an application date of April 19, 2002, an application number of 02801373.5, and an invention titled "Oral Drug Preparation and Oral Drug Preparation Holder". technical field [0002] The present invention relates to an orally administered preparation and an orally administered preparation support. Background technique [0003] Orally administered preparations may cause poor drug compliance due to discomfort caused by the bitterness or astringency of the drug, gas, vomiting, and refusal to take the drug. Therefore, formulations for oral administration in various dosage forms are being developed. [0004] Solid preparations such as tablets and capsules are used as general dosage forms of oral preparations. However, since these solid preparations are difficult to swallow directly, they usually have to be taken with a large amount of water, and sometimes they are difficult to swallow even when take...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/32A61K47/38A61K9/00A61K9/20
CPCA61K9/0053A61K9/7007A61P1/04A61K9/00
Inventor 野上英志
Owner LINTEC CORP