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Morselized foam for wound treatment

A technology of tiny particles and foam, used in pharmaceutical science, drug combination, absorbent pads, etc.

Inactive Publication Date: 2010-08-11
ETHICON INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Consequently, tissue-engineered scaffolds often fail to fuse into wounds because damage to any area of ​​the sheet would result in expulsion of the scaffold as a whole

Method used

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  • Morselized foam for wound treatment
  • Morselized foam for wound treatment
  • Morselized foam for wound treatment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1A

[0033] Example 1A: Preparation of Microparticle Foam and Controls

[0034] 35 / 65 (mol / mol%) poly(ε-caprolactone-co-glycolic acid) (PCL / PGA) copolymer (Ethicon, Somerville, NJ) in 1,4-dioxane A 5% (weight / volume percent) solution in hexane (Fisher Chemical, Ferrand, NJ) was prepared by adding one part polymer to nine parts solvent. The polymer and solvent are heated and stirred at about 60° C. for about 4-8 hours until the polymer dissolves. The polymer solution was filtered and approximately 10 grams of the solution was poured into an aluminum mold approximately 4.5 inches (114 mm) square and approximately 12.7 mm deep. The polymer solution filled molds were placed on the shelves of an FTS Dura dry freeze dryer pre-cooled to approximately -17 °C. After about 15 minutes the cycle was started and the temperature was held at -17°C for about 60 minutes. Vacuum was then applied to initiate primary drying of the dioxane by sublimation at about 100 mTorr for about 60 minutes. P...

Embodiment 1B

[0036] Microparticle foams were prepared as follows. The foam prepared as described in Example IA was cut into 1.5 x 1.5 cm sheets. Twelve foam sheets were prepared in a similar manner, individually bagged and sterilized using gamma irradiation. These foam sheets were used as controls. Microparticle foam samples were prepared by cutting six of sterile 1.5 x 1.5 cm foam sheets into approximately 1-4 mm pieces immediately prior to placement in the wound site.

Embodiment 2

[0037] Example 2: Porcine tissue repair and regeneration model

[0038] The purpose of this study was to determine the cell penetration and wound healing response of microparticle foams under full-thickness excision defects.

[0039] experimental design :

[0040] Two treatment groups were prepared for comparison. The first treatment group consisted of the fine particle foam prepared in Example IB. The second treatment group consisted of the foam sheet control. Full thickness excisional wounds (approximately 1.5 x 1.5 cm square) were made in the dorsal region of four pigs. The two treatment groups were randomly assigned to pigs and remained in this position throughout the study period. n=6 for each treatment group.

[0041] The foam sheet controls were trimmed to fit the wound and placed into the wound bed. Small particle foam blocks (approximately 13-35) are placed into the wound bed. Each wound was covered with a 2 x 2 cm wound dressing sold under the trade name N...

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Abstract

A wound treatment material comprising morselized foam is described. The morselized foam comprises a biocompatible, biodegradeable polymer. Methods for wound treatment and / or repair and / or regeneration of tissue using morselized foam are disclosed.

Description

technical field [0001] The invention discloses a wound treatment material comprising fine particle foam for wound treatment and / or tissue repair and / or regeneration. Background technique [0002] A wound is generally referred to as a disruption of normal anatomy and function, which can be internal (beneath the skin) or external (on the surface of the skin). Normal wound healing is characterized by the use of an orderly process to achieve wound closure (acute wounds) that includes a series of distinct but overlapping steps. Sometimes these processes are interrupted due to multiple mechanisms or underlying pathology (chronic wounds). Wounds differ in location and duration (acute or chronic) in addition to differing in underlying pathology. [0003] Acute wounds account for approximately one-tenth of the 2 billion wounds that occur each year in the United States and Western Europe. Acute wounds usually heal through the body's normal healing responses. Acute wounds include s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/26A61L15/42
CPCA61L15/425A61L15/26A61P43/00C08L67/04
Inventor L·J·布朗M·F·帕诺佐
Owner ETHICON INC