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Control system and method of radiation type flow direction bioreactor

A bioreactor and control system technology, applied in the field of biomedicine, can solve problems such as dead space and blockage, and achieve the effect of ensuring normal operation, eliminating invalid circulation and uniform exchange

Active Publication Date: 2012-05-23
ZHUJIANG HOSPITAL SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0014] The primary purpose of the present invention is to provide a kind of radiation type flow-to-bioreactor control system that can enhance the exchange efficiency and uniformity of the two fluids participating in the reaction when exchanging, and overcome the deficiencies such as dead space and blockage that exist during the exchange;

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  • Control system and method of radiation type flow direction bioreactor
  • Control system and method of radiation type flow direction bioreactor
  • Control system and method of radiation type flow direction bioreactor

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Embodiment Construction

[0046] Below in conjunction with accompanying drawing and embodiment the present invention will be further described:

[0047] The biochemical reaction between the first fluid and the second fluid referred to in the present invention can occur. Among the two fluids that need to undergo biochemical reactions, after one of the fluids undergoes a biochemical reaction with the second fluid, one of them can become the target object. The target object is the object that has achieved a certain purpose of preparation or treatment. The biochemical reaction carried out, more specifically, is due to the reaction between the first (type) substance fused or present in the first fluid and the second (type) substance fused or present in the second fluid. For example, in the stage of cell culture when simulating a bioartificial liver, the medium that dissolves the cells to be cultured is perfused in the bioreactor as the first fluid, the first substance in which is the cells, and then the nut...

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Abstract

The invention discloses a radiation type flow direction bioreactor as well as control system and method thereof. The radiation type flow direction bioreactor has the main improvement that in the bioreactor, a ligation member corresponding to a filter membrane between an outlet passage and an inlet passage is arranged nearby the inlet passage to change the flow direction of a second fluid enteringa reaction chamber and is provided with a shaft hole of a core shaft banding and coating the filter membrane, and the radius of the ligation member accounts for 3 / 10-7 / 10 of the radius of a barrel. The radiation type flow direction bioreactor comprehensively solves the problems of uneven perfusion, dead space, blockage, low exchange rate and the like existing in the traditional bioreactor.

Description

【Technical field】 [0001] The invention relates to the technical field of biomedicine, in particular to a control system and method for a radial flow bioreactor. 【Background technique】 [0002] Liver failure is the end-stage manifestation of various liver diseases. Patients are in critical condition, with high mortality and poor prognosis. Liver transplantation is currently recognized as the most effective treatment method, but due to lack of donors and high technical difficulty, the widespread implementation of liver transplantation is greatly restricted. The emergence of therapeutic methods such as bioartificial liver based on in vitro cultured hepatocytes is expected to provide an effective means for the modern treatment of liver failure just as the artificial kidney once revolutionized the treatment of renal failure. However, how to rationally design new biological responses The realization of long-term large-scale culture of hepatocytes in vitro is still the bottleneck ...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12M3/00
Inventor 周焕城高毅汪艳徐小平潘明新
Owner ZHUJIANG HOSPITAL SOUTHERN MEDICAL UNIV