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Traditional Chinese medicine extract with anti-HCV (hepatitis C virus) function

A comfrey extract and extraction technology, applied in the directions of antiviral agents, drug combinations, medical preparations containing active ingredients, etc., can solve the effective rate of less than 50%, the side effects of interferon therapy, and the patient's irritability, depression and fear. and other problems, to avoid iatrogenic diseases and low toxicity and side effects of traditional Chinese medicine

Inactive Publication Date: 2010-12-22
王喜军
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0002] Hepatitis C virus is referred to as HCV for short. It belongs to positive-strand RNA virus in terms of virus classification. The route of transmission is outside the gastrointestinal tract. , extrahepatic lesions, clinical treatment generally adopts interferon combined therapy, but the effective rate is less than 50%. At the same time, interferon therapy has many side effects, especially on the patient's psychology.
At present, there is no effective protective vaccine and specific drug against HC, therefore, the development of anti-HC drugs has become a top priority

Method used

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  • Traditional Chinese medicine extract with anti-HCV (hepatitis C virus) function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: the preparation of tablet

[0032] Take comfrey powder, put it into the extraction kettle, and use supercritical CO 2 As the extraction solvent, supercritical extraction technology is used for extraction. The extraction conditions are: extraction pressure 17MPa, extraction temperature 40°C, analysis pressure 5Mpa, analysis temperature 40°C, flow rate 25L / h, extraction time 1.5h, and the comfrey extract is obtained. Add conventional excipients, according to conventional technology, make pharmaceutically acceptable tablet, be used for treating hepatitis C.

Embodiment 2

[0033] Embodiment 2: the preparation of pill

[0034] Take comfrey powder, put it into the extraction kettle, and use supercritical CO 2 As the extraction solvent, supercritical extraction technology is used for extraction. The extraction conditions are: extraction pressure 15MPa, extraction temperature 56°C, analysis pressure 7Mpa, analysis temperature 32°C, flow rate 18L / h, extraction time 2.5h, and the comfrey extract is obtained. Add conventional excipients, according to conventional technology, make pharmaceutically acceptable pills, used for treating hepatitis C.

Embodiment 3

[0035] Embodiment 3: the preparation of capsule

[0036] Take comfrey powder, put it into the extraction kettle, and use supercritical CO 2 As the extraction solvent, supercritical extraction technology is used for extraction. The extraction conditions are: extraction pressure 32MPa, extraction temperature 35°C, analysis pressure 4Mpa, analysis temperature 56°C, flow rate 38L / h, extraction time 1h, to obtain comfrey extract, add Conventional excipients are prepared into pharmaceutically acceptable capsules according to conventional processes for treating hepatitis C.

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PUM

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Abstract

The invention discloses a traditional Chinese medicine extract with anti-HCV (hepatitis C virus) function as well as a preparation method and use thereof. In the invention, the new method of treating the hepatitis C by using a shikone extract is used, and the effectiveness of resisting HCV PR with the shikone can be a new lightspot for researching anti-HCV medicines. Meanwhile, the characteristic of low poison side effect of the traditional Chinese medicine can enable the shikone to become a safer effective medicine to avoid the occurrence of nosocomial diseases; the successful research of the shikone can make about 2-3 percent global HCV infectors to get rid of puzzles that the hepatitis C is deteriorated to chronic hepatitis, hepatocirrhosis and liver cancer, so as to remove the HCV from the notation of infectious diseases which severely influence human health.

Description

field of invention [0001] The invention relates to a traditional Chinese medicine extract, in particular to a traditional Chinese medicine extract with anti-hepatitis C virus effect and a preparation method thereof. Background technique [0002] Hepatitis C virus is referred to as HCV for short. It belongs to positive-strand RNA virus in terms of virus classification. The route of transmission is outside the gastrointestinal tract. , extrahepatic lesions, clinical treatment generally adopts interferon combined therapy, but the effective rate is less than 50%. At the same time, interferon therapy has many side effects, especially on the patient's psychology. The patient may have irritability, depression and fear. At present, there is no effective protective vaccine and specific drug against HC. Therefore, the development of anti-HC drugs has become a top priority. Contents of the invention [0003] The object of the present invention is to disclose a kind of Chinese medici...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/30A61P1/16A61P31/14B01D11/02
Inventor 王喜军孙晖吴修红徐红英
Owner 王喜军