Preparation method of D-ribose
A ribose and nucleoside technology, applied in the new field of D-ribose preparation, can solve the problems of inability to realize industrial production, low D-ribose purity, unsatisfactory purification effect, etc., and achieves reduced post-processing difficulty, easy purification, and less impurities Effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0011] Add 30g of inosine and 1000ml of water into the reaction flask, raise the temperature to above 90°C, add S 2 o 8 2- / TiO 2 0.5g, and then keep warm for 3 hours, spot the plate to confirm that there is no inosine in the reaction. The temperature was lowered to room temperature, and the catalyst and hypoxanthine were filtered off. The liquid was concentrated under reduced pressure until anhydrous was distilled off, and dried to obtain 16.6 g of D-ribose, with a yield of 98.9%. It was confirmed by high performance liquid chromatography that the D-ribose has excellent related properties, as described in Table 1.
Embodiment 2
[0013] Add 30g of inosine and 1000ml of water into the reaction flask, raise the temperature to above 90°C, add S 2 o 8 2- / TiO 2 0.7g, and then incubated for 3 hours to confirm that there was no inosine in the reaction. The temperature was lowered to room temperature, and the catalyst and hypoxanthine were filtered off. The liquid was concentrated under reduced pressure until anhydrous was distilled off, and dried to obtain 16.5 g of D-ribose, with a yield of 98.3%. It was confirmed by high performance liquid chromatography that the D-ribose has excellent related properties, as described in Table 1.
Embodiment 3
[0015] Add 30g of guanosine and 1000ml of water into the reaction flask, raise the temperature to above 90°C, add S 2 o 8 2- / TiO 2 1.0 g, then incubated for 3 hours, and spotted to confirm that there was no inosine in the reaction. The temperature was lowered to room temperature, and the catalyst and guanine were filtered off. The liquid was concentrated under reduced pressure until anhydrous was distilled off, and dried to obtain 15.6 g of D-ribose, with a yield of 98.1%. It was confirmed by high performance liquid chromatography that the D-ribose has excellent related properties, as described in Table 1.
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More