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Medicinal composition for hypoxia resistance

A composition and hypoxia-resistant technology, which is applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problem of few effective parts of traditional Chinese medicine compound, and achieve the effect of prolonging hypoxia-resistant time and obvious hypoxia-resistant effect

Inactive Publication Date: 2011-01-26
YANCHENG INST OF HEALTH SCI
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Problems solved by technology

Judging from the literature, the current research on the pharmacological effects of active ingredients of traditional Chinese medicine on hypoxia resistance mostly uses the effective parts of single Chinese medicines, and seldom studies the effective parts of traditional Chinese medicine compounds.

Method used

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  • Medicinal composition for hypoxia resistance

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Embodiment Construction

[0010] 1. drug preparation

[0011] 1.1 Preparation of total flavonoids from chrysanthemum:

[0012] Take the white chrysanthemum flower produced in Jiangsu, crush it, add 10 volumes of 70% ethanol to reflux and extract twice (6 times, 4 times), each time for 2 hours, combine the extracts, recover the solvent to a relative density of 1.2 liquid extracts, add water to dilute into each One milliliter is equivalent to 0.2g of crude drug. Filtrate, and the filtrate is ready for use (the measured total flavonoid content is 15.07mg.mL-1). The pretreated D101 macroporous adsorption resin is packed in a wet column, and the column volume is 100mL (wet weight 66g, dry weighs 18g), the ratio of diameter to height is 1:8, precisely pipette 400mL of upper column liquid onto the column, and control the flow rate to 6 mL / min. Then use 3 times the column volume of purified water and 1 times the column volume of 20% ethanol to elute the impurities, control the flow rate to 6 mL / min, then u...

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Abstract

The invention relates to a medicinal composition for prolonging the hypoxia resistant survival time of mice under constant pressure, which is prepared from chrysanthemum general flavones and amaranthaceae saponins in a weight ratio of 2:1. The general flavone content of the chrysanthemum general flavones is more than or equal to 60 percent (which is measured by a UV method), luteolin-7-O-D-glucoside is more than or equal to 0.3 percent (which is measured by a HPLC method), and the general flavone content of the amaranthaceae saponins is more than or equal to 70 percent (which is measured by the UV method). The medicinal composition can prolong the hypoxia resistant survival time of the mice under the constant pressure, and has the obvious hypoxia resistant effect.

Description

technical field [0001] The invention relates to a pharmaceutical composition for hypoxia tolerance. Background technique [0002] Chrysanthemum is Chrysanthemummorifoliumat. ) Dry flower heads of Tzvel. There are more than 30 species of chrysanthemums in the world, and about 17 species in China, but the main one that is cultivated for medicinal purposes is chrysanthemum. Different medicinal varieties, such as Chuju, Haoju, Jiju, Huaiju, Hangju, Gongju, Qiju, Huangju and so on. The main active ingredients of chrysanthemum are volatile oil and flavonoids. Studies have shown that the crude extract of chrysanthemum has various pharmacological effects such as antibacterial, anti-inflammatory, analgesic, anti-viral, anti-aging, anti-tumor, anti-mutagenic, and increases coronary flow in isolated guinea pig hearts. However, the pharmacological activity of chrysanthemum total flavonoids (the content of total flavonoids is not less than 60%) as an effective part of hypoxia resista...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P39/00
Inventor 卞庆亚蔡红星罗崇念王树树秦红兵王宁熊存全
Owner YANCHENG INST OF HEALTH SCI