Hair care compositions and methods for increasing hair diameter and delivering additional benefits
A technology for hair care, beneficial effects, applied in the field of hair care compositions, capable of solving problems such as increased diameter of hair fibers
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Examples
Embodiment 1
[0102] Example 1: Clinical Research
[0103] Compositions comprising a mixture of caffeine, niacinamide and panthenol showed a clinically significant increase in hair width relative to placebo. In this study, a water / alcohol based (25% ethanol, qs. water) scalp tonic containing 5% niacinamide, 1.5% caffeine and 0.3% D-panthenol was evaluated. This formulation also contained 0.3% hydroxypropylmethylcellulose as a thickening agent. In this half-head study, 1.5 mL of tonic was administered twice daily on one side of the head and 1.5 mL of placebo was administered twice daily on the other side of the head.
[0104] This is a 14-week double-blind randomized half-head controlled clinical study of women aged 18-65 (inclusive) who perceive themselves to have thinning hair. The study consisted of a 2-week pre-treatment period (placebo was administered on both sides of the head for proper product application prior to the actual treatment period), followed by a 12-week treatment peri...
Embodiment 2
[0112] Example 2: Synergy Research
[0113] A mixture of caffeine, niacinamide and panthenol showed a surprising increase in the viability of metabolically stressed dermal papilla cells relative to the individual components as well as relative to a mixture of two of them, as shown below. The dermal papilla in normal human hair is the control center of hair diameter. Increased viability of dermal papilla cells in situ, resulting in an increase in hair diameter. Thus, increased viability of dermal papilla cells correlates with increased hair diameter.
[0114] Primary human dermal papilla cells were metabolically stressed for 48 hours in meiotic standard tissue culture medium. During this stress period, the cells were treated with the mixtures or individual components described below. After 48 hours, use Cell Titer Glo TM Kit (Promega), the metabolic activity of cells was determined according to the amount of ATP.
[0115]
Embodiment 3
[0116] Example 3: Hair Care Composition Example
[0117] tonic
[0118]
[0119]
[0120] mousse
[0121] Components (active substance weight%)
D
E
F
caffeine
1.5
-
0.8
Caffeine Benzoate
-
1.0
-
5.0
-
-
Niacinamide Ascorbate
-
2.0
1.0
panthenol
0.3
-
0.1
panthenyl triacetate
-
0.3
-
[0122] glycerin
5.0
1.0
1.0
carbomer
-
0.1
0.1
-
0.2
0.2
1.0
-
-
1.5
-
-
pvp
-
0.2
0.2
Ethylhexyl hexadecanoate
0.2
0.3
0.2
1,3-Butanediol
2.0
5.0
5.0
Polysorbate 20
1.0
1.5
1.5
6.0
6.0
6.0
3.0
1.0
-
...
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Abstract
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