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Self-emulsified fish oil soft capsules without fishy smell

A technology of self-emulsifying and soft capsules, which is applied in capsule delivery, medical raw materials derived from fish feed, medical preparations with non-active ingredients, etc., can solve problems such as low bioavailability, unfavorable absorption, and difficulty in swallowing, and achieve Improve bioavailability, promote absorption, and good dispersion

Inactive Publication Date: 2011-02-02
MAITE SHANGHAI BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The existing cod liver oil composition contains cod liver oil and vitamin E, which is not conducive to absorption and low bioavailability, and it has a fishy smell when taken directly by infants and young children, the taste is not good, and it is difficult to swallow

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A fish oil soft capsule, comprising an outer skin and contents, the contents are composed of 96 parts by weight of fish oil, 0.3 parts by weight of vitamin E, 2 parts by weight of tea green pigment and 2 parts by weight of polyglycerol fatty acid ester.

[0017] Its preparation method is:

[0018] (1) Soak the tea leaves in 85% ethanol solution at a weight ratio of 1:5 for 4 hours, filter, concentrate the filtrate under reduced pressure to obtain an extract, adjust the pH to 2 with 2M phosphoric acid, and precipitate out, use 95 % ethanol to wash the separated precipitate, and the resulting dark green paste is tea green pigment;

[0019] (2) Vitamin E, tea green pigment and emulsifier were added to the fish oil in proportion under the condition of mechanical stirring at 60rpm, gelatinized gum was used as the outer skin component, and soft capsules were made by a pill making machine. Net weight 1000mg. Take 1-4 capsules daily.

Embodiment 2

[0021] A cod liver oil soft capsule comprises an outer skin and contents, wherein the contents are composed of 90 parts by weight of fish oil, 0.2 parts by weight of vitamin E, 5 parts by weight of tea green pigment and 5 parts by weight of PEG400.

[0022] Its preparation method and administration method are the same as in Example 1.

Embodiment 3

[0024] A cod liver oil soft capsule comprises a skin and contents, the contents are composed of 85 parts by weight of fish oil, 0.02 parts by weight of vitamin E, 10 parts by weight of tea green pigment and 5 parts by weight of sucrose ester.

[0025] Its preparation method and administration method are the same as in Example 1.

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PUM

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Abstract

The invention provides self-emulsified fish oil soft capsules without fishy smell, which comprise scarfskin and inclusion. The soft capsules are characterized by consisting of the following components in part by weight: 85 to 98 parts of fish oil, 0.01 to 0.5 part of vitamin E, 1 to 10 parts of tea chlorophyll and 1 to 5 parts of emulsifying agent. The soft capsules have the advantages of capability of self-emulsifying, high bioavailability, no fishy smell, good mouthfeel and convenience for administration.

Description

technical field [0001] The invention relates to a fish oil soft capsule with no fishy smell and self-emulsification. Background technique [0002] The main effective components of fish oil are Omega-3 polyunsaturated fatty acids, the main components of which are DHA and EPA. [0003] EPA is eicosapentaenoic acid, a special unsaturated fatty acid, which has many protective factors beneficial to blood circulation, including: (1) assisting obese patients, patients with high blood pressure and hyperlipidemia to maintain a high degree of blood fluidity , inhibit abnormal blood coagulation, prevent the occurrence of thrombus and stroke and myocardial infarction; (2) assist in removing cholesterol and hardened plaque attached to the blood vessel wall, reduce bad cholesterol in the blood, and maintain good elasticity of blood vessels (3) Assist people with poor fat metabolism (including patients with high triglycerides and diabetes patients) to reduce triglycerides to avoid fat acc...

Claims

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Application Information

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IPC IPC(8): A61K9/48A23L1/327A61K47/46A61K31/355A61P3/02A23L1/29A61K35/60A23L17/20A23L33/00
Inventor 杨卫国刘艳杨月芬
Owner MAITE SHANGHAI BIOLOGICAL TECH