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High-purity glutamic acid and preparation method thereof

A glutamic acid and high-purity technology, which is applied in the field of high-purity glutamic acid and its preparation, can solve the problems of low product yield, high glutamic acid impurities, environmental pollution and other problems in the purification method, so as to reduce the difficulty of environmental protection treatment and product The effect of high yield

Inactive Publication Date: 2014-12-03
LOTUS HEALTH GROUP COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide a kind of high-purity glutamic acid and preparation method thereof, overcome the defect that the glutamic acid prepared by the existing method has many impurities, the product yield of the purification method is low, the loss of active ingredients and the environmental pollution caused by the discharge of waste liquid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] High-purity glutamic acid with a glutamic acid content of not less than 99% is prepared from glutamic acid fermentation broth.

[0029] Proceed as follows:

[0030] 1) Concentrate glutamic acid fermentation liquid: turn on the vacuum pump of the five-effect falling film evaporator, and after the vacuum degree of the fifth-effect separator reaches -0.07MPa, pump in fresh fermentation liquid and turn on the circulating pump to concentrate the glutamic acid fermentation liquid to The concentration is 32mg / 100ml;

[0031] 2) Continuous isoelectric extraction of glutamic acid: pump the glutamic acid concentrate prepared in step 1) and the glutamic acid mother liquor obtained in step 5) of sulfuric acid hydrolysis into the continuous isoelectric tank containing the base material, and control the isoelectric The acidity of the tank is pH3.22, and the bottom material here is a glutamic acid solution containing a large amount of small glutamic acid crystals. After the crystal g...

Embodiment 2

[0042] Using common glutamic acid as raw material to prepare high-purity glutamic acid, the steps are as follows:

[0043] 1) Dissolution and crystallization: Dissolve the β-type glutamic acid crystal washing water separated by the belt separator in step 2) of common glutamic acid to a mass concentration of about 40%, and pump it into the glutamic acid crystallization tank from the bottom to control the glutamic acid Acid crystallization temperature is 75°C, and crystallization time is 3 hours;

[0044]2) Cooling and separation: the glutamic acid metamorphic liquid overflowed from the metamorphic tank is introduced into the cooling tank in two-stage series, the temperature is lowered to 20°C, and pumped into the belt separator to separate glutamic acid with a content of about 97%. β-type crystalline glutamic acid, the glutamic acid mother liquor separated from the front section of the belt separator is hydrolyzed with sulfuric acid as an isoelectric acid solution, and the glut...

Embodiment 3

[0052] The preparation of high-purity glutamic acid from metamorphic glutamic acid or its solution is as follows:

[0053] 1) Neutralization: adding metamorphic glutamic acid or its solution into a NaOH solution with a mass concentration of 30% for complete neutralization to prepare a sodium glutamate solution with a pH of 6.99 and a mass concentration of 45%;

[0054] 2) Decolorization and iron removal: the sodium glutamate solution prepared in step 1 is sequentially passed through activated carbon-iron removal resin column-activated carbon column to remove impurities and pigments in the sodium glutamate solution;

[0055] 3) Acidification: Add hydrochloric acid to the refined sodium glutamate solution prepared in step 2), adjust the acidity to pH 4.5, and the temperature is 25°C. After the crystals are formed, grow the crystals for 2 hours, adjust the acidity to pH 3.0, and the temperature is 17°C , to prevent crystal precipitation.

[0056] 4) Cooling: Stir the glutamic ac...

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Abstract

The invention belongs to the technical field of glutamic acid purification, and particularly relates to high-purity glutamic acid and preparation method thereof. In the preparation method, glutamate, metacrystal glutamic acid solution or glutamic acid fermentation liquor is used as a raw material; and according to different raw materials, the purification of the glutamic acid is finished through multiple times of crystallization, separation and crystal cleaning to ensure that the glutamic acid content reaches over 99 percent. The high-purity glutamic acid provided by the invention can be used as a pharmaceutical grade glutamic acid precursor; and the preparation method has a high product yield, the effective components in the generated waste liquor can be fully used, and environmental treatment difficulties of waste water are reduced.

Description

(1) Technical field [0001] The invention belongs to the technical field of glutamic acid purification, in particular to a high-purity glutamic acid and a preparation method thereof. (2) Background technology [0002] Glutamic acid plays an important role in the protein metabolism process in organisms, and participates in many important chemical reactions in animals, plants and microorganisms. Medically, glutamate is mainly used to treat hepatic coma, and is also used to improve children's intellectual development. In the food industry, monosodium glutamate is a commonly used freshness enhancer, and its main component is sodium glutamate. The umami taste of edible MSG can stimulate taste cells and excite digestive glands, increase appetite, promote digestion, improve the body's ability to absorb various other foods, and have a certain nourishing effect on the human body. Glutamic acid can also combine with blood ammonia to form glutamine, which is harmless to the body, reli...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C229/24C07C227/42C07C227/40C07C227/18C05G1/00
Inventor 高君张国庆赵二红王新春谷丰张顺棠郭明井金峰田晓燕
Owner LOTUS HEALTH GROUP COMPANY