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Water-soluble fluorescent magnetic nano particles and preparation method thereof

A technology of magnetic nanometer and magnetic composite nanometer, applied in the field of water-soluble fluorescent magnetic nanoparticle and its preparation, can solve the problems of limiting wide application, and achieve the effects of excellent fluorescence, good magnetic responsiveness, and avoiding fluorescence quenching effect.

Inactive Publication Date: 2014-01-22
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Summarize the quantum dots selected for the preparation of fluorescent magnetic composite nanoparticles. At present, Cd-type quantum dots are commonly used, but these quantum dots have limited their wide application in life medicine due to biological toxicity.

Method used

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  • Water-soluble fluorescent magnetic nano particles and preparation method thereof
  • Water-soluble fluorescent magnetic nano particles and preparation method thereof
  • Water-soluble fluorescent magnetic nano particles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Preparation of quantum dot solution

[0032] Under nitrogen protection, 0.0085g NaBH 4 Dissolve 0.0059g of Se powder in 2ml of distilled water, heat to 30°C, and completely dissolve to obtain NaSeH solution, which is the Se precursor; take 0.1317g of Zn(Ac) 2 Dissolve in 20 ml of distilled water, add 50 μl of TGA after it is completely dissolved, and adjust the pH to 9.5 with 1 mol / L NaOH solution to obtain the Zn precursor. Transfer the Zn precursor into a three-necked flask, quickly inject the Se precursor under the protection of nitrogen, reflux in an oil bath (90°C), stir magnetically for 1 hour, take it out and put it in a refrigerator to cool to room temperature to obtain an aqueous solution of ZnSe quantum dots.

[0033] (2) Preparation of magnetic nanoparticles

[0034] (a) Fe 3 o 4 Preparation of Magnetic Nanoparticles

[0035] Weigh 2.7802g FeSO 4 ·7H 2 O, 4.3248g FeCl 3 ·6H 2 O is placed in two 200ml beakers, each of which is added with 30ml of d...

Embodiment 2

[0041] (1) Preparation of quantum dot solution

[0042] Under nitrogen protection, 0.0085g NaBH 4 Dissolve 0.0059g of Se powder in 2ml of distilled water, heat to 30°C, and completely dissolve to obtain NaSeH solution, which is the Se precursor; take 0.1317g of Zn(Ac) 2 Dissolve in 20 ml of distilled water, add 45 μl of TGA after it is completely dissolved, and adjust the pH to 8 with 1 mol / L NaOH solution to prepare the Zn precursor. Transfer the Zn precursor into a three-necked flask, quickly inject the Se precursor under the protection of nitrogen, reflux in an oil bath (90°C), stir magnetically for 1 hour, take it out and put it in a refrigerator to cool to room temperature to obtain an aqueous solution of ZnSe quantum dots.

[0043] (2) Preparation of magnetic nanoparticles

[0044] (a) Fe 3 o 4 Preparation of Magnetic Nanoparticles

[0045] Step is as in embodiment 1, change preparation Fe 3 o 4 The amount of raw materials during magnetic nanoparticles, respective...

Embodiment 3

[0052] (1) Preparation of quantum dot solution

[0053] Under nitrogen protection, 0.0085g NaBH 4 Dissolve 0.0059g of Se powder in 2ml of distilled water, heat to 30°C, and completely dissolve to obtain NaSeH solution, which is the Se precursor; take 0.1317g of Zn(Ac) 2 Dissolve in 20 ml of distilled water, add 88 μl of TGA after it is completely dissolved, and adjust the pH to 11 with 1 mol / L NaOH solution to prepare the Zn precursor. Transfer the Zn precursor into a three-necked flask, quickly inject the Se precursor under nitrogen protection, reflux in an oil bath (90°C), stir magnetically, take it out for 1 hour and put it in a refrigerator to cool it to room temperature to obtain an aqueous solution of ZnSe quantum dots.

[0054] (2) Preparation of magnetic nanoparticles

[0055] (a) Fe 3 o 4 Preparation of Magnetic Nanoparticles

[0056] Weigh 0.8901g FeSO 4 ·7H 2 O, 2.1624g FeCl 3 ·6H 2 O is placed in two 200ml beakers, each of which is added with 30ml of disti...

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Abstract

The invention belongs to the field of nano material preparation, and particularly relates to water-soluble fluorescent magnetic nano particles and a preparation method thereof. The invention adopts the technical scheme that the method comprises the following steps of: preparing magnetic nano particles by adopting a solvent thermal method, coating a SiO2 shell layer on the surface of the magnetic nano particles by hydrolysis of ethyl orthosilicate under the alkali condition, and connecting -NH2 to the outermost layer through a silane coupling agent with amino; and finally, mixing two kinds of aqueous solution, adding a connecting agent such as ethylene dichloride (EDC) or the like, and connecting the magnetic nano particles and quantum dots through chemical bonds formed by condensation reaction between amino and carboxyl to obtain the fluorescent magnetic nano particles. The fluorescent magnetic nano particles obtained by the technical scheme have low toxicity, good stability and magnetic response and excellent fluorescence; and the method has short experimental period, simple and safe operation and low raw material cost, can be completed in a common chemical laboratory, and lays a foundation for wide popularization and application.

Description

Technical field: [0001] The invention belongs to the field of preparation of nanometer materials, and in particular relates to a water-soluble fluorescent magnetic nanoparticle and a preparation method thereof. Background technique: [0002] Quantum dots (QDs), also known as nanocrystals, are nanoparticles composed of II-VI or III-V elements. The particle size of quantum dots is generally between 1-10nm. Due to the small particle size, electrons and holes are quantum-confined, and the continuous energy band becomes a discrete energy level structure with molecular characteristics, which can emit fluorescence after being excited. Due to the advantages of high luminous intensity, good photostability, easy excitation and narrow luminous wavelength range, semiconductor quantum dot materials have gradually replaced traditional organic fluorescent dyes and have been used as a new fluorescent marker in many fields such as medical diagnosis. middle. In 1998, Chan and Nie et al. (Ch...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/88C09K11/56H01F1/33B82Y30/00B82Y40/00
Inventor 刘福田王群孙雪娇姜庆辉王冬至张爱玉曹永强杨萍
Owner UNIV OF JINAN