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Eradicating agent and eradication method for helicobacter pylori

A kind of technology of Helicobacter pylori and expelling agent, applied in the field of expelling agent of Helicobacter pylori

Inactive Publication Date: 2012-08-22
ANTHRAX SPORES KILLER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] On the other hand, as a method that does not rely on drugs, there are also reports that the administration of special lactic acid bacteria and daily intake of foods with antibacterial effects such as prunes are effective, but the actual situation is that many experts question its effectiveness.

Method used

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  • Eradicating agent and eradication method for helicobacter pylori
  • Eradicating agent and eradication method for helicobacter pylori
  • Eradicating agent and eradication method for helicobacter pylori

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Experimental program
Comparison scheme
Effect test

Embodiment

[0068] Hereinafter, the process of development of the present invention will be sequentially described.

[0069] First, we will start with the successful cases of treatment methods for chronic infectious diseases that have been difficult to cure until now that do not rely on surgery as teaching materials.

[0070] As an example, there is dermatophytosis, which is caused by parasitic reproduction of trichophyton on the stratum corneum of the skin surface, using the protein (keratin) of the stratum corneum as a nutrient source for reproduction, and when it is located from the ankle to the toe, it is commonly called For tinea pedis, in the past, drugs were only applied from the outside, but now the combination of less toxic imidazole antifungal drugs and conventional external drugs is mainly used according to the symptoms. That is, by attacking the trichophyton from the inside and the outside, the stubborn athlete's foot called incurable is almost completely cured.

[0071] In a...

manufacture example 1

[0113] Production example 1 (1000ml)

[0114] FeCl 3 ·6H 2 O 0.96g

[0115] L-cysteine ​​1g

[0116] L-Ascorbic Acid 0.1g

[0117] Potassium sorbate 0.05g

[0118] Sodium Lauryl Sulfate 0.1g

[0119] 3N HCl 1ml

[0120] water rest

[0121] As can be seen from the above table, any kind of sterilizing solution can kill pylori bacteria in about 10 seconds of contact.

[0122] Then, add 10% and 20% of the above-mentioned various bactericidal solutions of Skirrow medium respectively, inoculate pylori bacteria for cultivation, and only the Helicobacter pylori sterilizing solution exerts a strong antibacterial effect, so as to inhibit the growth or death of pylori bacteria. These results are shown in Table 4.

[0123] Table 4 Bactericidal effect when adding bactericidal solution to the culture medium

[0124]

[0125] Evaluation criteria are the same as Table 1

[0126] The test results truthfully show that in the presence of organic matter, the bactericidal components ...

manufacture example

[0168]

[0169] * Solution [I]: Dissolve 0.32g FeCl in 200ml purified water 3 ·6H 2 o

[0170] Solution [II]: 0.2 g of L-cysteine, 0.02 g of L-ascorbic acid, and 0.01 g of sodium lauryl sulfate were dissolved in 800 ml of purified water.

[0171] Next, solution [I] and solution [II] were mixed, and 1 ml of 3 N hydrochloric acid (pH 3.0) was added. B to E also use the same manufacturing method.

[0172] [2] Expulsion, sanitization from the inside

[0173] Combination of antibiotics and gastric acid secretion inhibitors, which are currently widely practiced as a method for eradicating pylori bacteria, follows.

[0174] 2 doses of penicillin-type amoxicillin (AMPC) and macrolide-type clarithromycin (CAM) that are applicable to health insurance orally for 7 consecutive days twice a day (morning and after dinner) and gastric acid secretion inhibitors The success rate of 3 doses of proton pump inhibitor (PPI) lansoprazole or omeprazole is said to be 80%, but if according to...

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Abstract

Disclosed is a Helicobacter pylori eradicating agent comprising a metal ion having an antibacterial activity, L-cysteine and L-ascorbic acid as the main ingredients and further comprising a surfactant excluding a nonionic surfactant. The Helicobacter pylori eradicating agent is highly safe, and can be used in combination with at least one antibiotic selected from the group consisting of amoxicillin, clarithromycin and a proton pump inhibitor to substantially kill a Helicobacter pylori cell that has been difficult to eradicate heretofore in a carrier of the Helicobacter pylori cell within a short period. Also disclosed is a Helicobacter pylori eradication method.

Description

technical field [0001] The present invention relates to an agent and method for repelling Helicobacter pylori, which infects, fixes, and proliferates in gastric mucosa and gastric mucus, and develops from chronic gastritis to gastroduodenal ulcer and then becomes an inducement of gastric cancer. Background technique [0002] As the cause of gastric cancer and gastroduodenal ulcer, immunological research shows that it is related to the chronic gastric mucosal infection of Helicobacter pylori. It is recommended to start with the prevention and treatment of the disease for its expulsion and sterilization. [0003] The bacterium was first isolated from human gastric mucosa in 1982 and discovered. It is said that 70% of Japanese people over the age of 40 are infected, and it is now recognized as a national disease. Gram-negative spiral bacilli with extremely hairy flagella are the main species, and they grow and multiply close to the surface of gastric mucosal epithelial cells a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/00A61K31/198A61K31/375A61K33/26A61K33/30A61K33/34A61K33/38A61K47/18A61K47/20A61K47/34A61P31/04
CPCA61K33/00A61K33/26A61K9/0053A61K33/38A61K33/34A61K9/0095A61K33/30A61K31/375A61K31/198A61K45/06A61P1/04A61P31/04A61K2300/00
Inventor 秦忠世秦知世真木修一丸冈俊之
Owner ANTHRAX SPORES KILLER