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Selegiline-containing adhesive preparation

A preparation and pressure-sensitive adhesive technology, applied in the field of adhesive preparations, can solve the problems of no disclosure or hint of the stability of selegiline, and achieve the effect of high stability and low amount of impurities

Inactive Publication Date: 2011-09-21
NITTO DENKO CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is nothing disclosed or implied in this reference about selegiline and its stability

Method used

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  • Selegiline-containing adhesive preparation
  • Selegiline-containing adhesive preparation
  • Selegiline-containing adhesive preparation

Examples

Experimental program
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Effect test

Embodiment

[0067] The present invention is described in detail below with reference to Examples, however, the present invention is not limited to these Examples. In this connection, the term "part" used in the following description means "part by weight".

[0068] (Preparation of Acrylic Pressure Sensitive Adhesives)

[0069] Under an inert gas atmosphere, dissolve 72 parts of 2-ethylhexyl acrylate, 25 parts of N-vinyl-2-pyrrolidone, 3 parts of acrylic acid and 0.2 parts of azobisisobutyronitrile in ethyl acetate at 60°C Solution polymerization was performed to prepare a solution of an acrylic pressure-sensitive adhesive. The weight average molecular weight of the acrylic pressure sensitive adhesive is about 1,800,000.

[0070] (Preparation of Adhesive Preparations Containing Selegiline of Examples 1-9 and Comparative Examples 1-5)

[0071] Various pressure-sensitive adhesive solutions were prepared according to the blending ratio shown in Table 1 below, and the solutions thus obtaine...

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Abstract

The present invention provides an adhesive preparation, which includes a backing and a pressure-sensitive adhesive layer formed on at least one side of the backing, the pressure-sensitive adhesive layer containing (-)-(R)-N,[alpha]-dimethyl-N-2-propynylphenethylamine and / or a pharmaceutically acceptable salt thereof, a pressure-sensitive adhesive and one or two or more stabilizers selected from the group consisting of 2-mercaptobenzimidazole, sodium sulfite, butylhydroxyanisole and butylhydroxytoluene.

Description

technical field [0001] The present invention relates to an adhesive preparation comprising (-)-(R)-N,α-dimethyl-N-2-propynylphenethylamine (hereinafter referred to as "selegiline) free form") and / or a pharmaceutically acceptable salt of (-)-(R)-N,α-dimethyl-N-2-propynylphenethylamine (hereinafter referred to as "selegiline salt of selegiline", which and the above-mentioned "free form of selegiline" are collectively referred to as "selegiline"). Background technique [0002] The anti-Parkinson's drug selegiline is known as an inhibitor of monoamine oxidase (MAO), and it is also known that there are different subtypes of MAO, namely, type A (MAO-A) and type B (MAO-B), selegiline Legiline is a selective inhibitor of MAO-B. On the other hand, it is known that selegiline also inhibits MAO-A when it is orally administered in a large amount, and it shows an antidepressant effect. However, since many MAO-A are present in digestive organs, when MAO-A is inhibited by oral administr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/137A61K47/22A61K47/32A61P25/16A61P25/24A61P25/00A61P25/08A61P25/18A61P25/28A61P27/06A61P39/06A61P1/08
CPCA61K47/02A61K9/7061A61K47/10A61K47/22A61K31/137A61P1/08A61P25/00A61P25/02A61P25/08A61P25/14A61P25/16A61P25/18A61P25/24A61P25/28A61P27/06A61P39/06A61P43/00A61K9/7038A61K31/135
Inventor 井之阪敬悟雨山智中村光史关谷纯一
Owner NITTO DENKO CORP