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Method for preparing infantile lung clearing and phlegm eliminating preparation

A technology for clearing lung and resolving phlegm and preparations, which is applied in the directions of pharmaceutical formulas, medical preparations containing active ingredients, active ingredients of aluminum/calcium/magnesium, etc., can solve the problems of enzymatic decomposition, high loss and poor product stability of bitter almonds, etc. To achieve the effect of preventing hydrolysis, improving extraction rate and improving curative effect

Active Publication Date: 2012-11-07
SHINEWAY PHARMA GRP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the ephedrine in the drug formula is volatile, and it loses more when it is extracted and concentrated at high temperature; the chemical property of amygdalin is unstable, it is easily destroyed by acid and alkali, and it is more likely to be decomposed by amygdalin; therefore, this method is not conducive to formulating The active ingredients of each component are enriched, the product stability is poor, and the efficacy of the drug needs to be further improved

Method used

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  • Method for preparing infantile lung clearing and phlegm eliminating preparation
  • Method for preparing infantile lung clearing and phlegm eliminating preparation
  • Method for preparing infantile lung clearing and phlegm eliminating preparation

Examples

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Embodiment 1

[0019] Prescription: Ephedra 30g, Gypsum 225g, Bitter almond 75g, Peucedanum 75g, Scutellaria baicalensis 75g, Perilla (fried) 75g, Tinglizi 93g, Zhuru 75g.

[0020] Preparation method: Take the above eight flavors, take ephedra and crush it into coarse powder; take 2 times the amount of water, adjust it to an acidic aqueous solution with a pH value of 3, soak the ephedra coarse powder, soak for 2 days, then carry out percolation extraction, and collect 8 times the percolation liquid , adjust the pH to 6, filter and concentrate for later use; after the bitter almonds are broken, quickly inactivate the enzyme with circulating steam for 40 minutes, add 1 times the amount of 30% ethanol to soak the bitter almonds after the enzyme inactivation for 2 days, and then carry out percolation, and collect 6 times the percolation liquid , filtered and concentrated, set aside. Add gypsum and water to decoct for 1 hour, then add Peucedanum, Scutellaria baicalensis, perilla seeds (stir-fried...

Embodiment 2

[0022] Prescription: Ephedra 40g, Gypsum 60g, Bitter almond 90g, Peucedanum 90g, Scutellaria baicalensis 90g, Perilla (fried) 90g, Tinglizi 120g, Zhuru 90g.

[0023] Preparation method: Take the above eight flavors, take ephedra and crush it into coarse powder, add 1 times the amount of acidic aqueous solution with a pH value of 4 to soak for 1 day, then carry out percolation extraction, collect 16 times the percolation liquid, adjust the pH to 6, filter and concentrate for later use; bitter almonds Immediately after crushing, inactivate the enzyme with circulating steam for 30 minutes, take the enzyme-inactivated bitter almonds, add 1 times the amount of 50% ethanol to soak for 2 days, and then percolate, collect 7 times the percolation liquid, filter and concentrate, and set aside. Add water to the gypsum and boil it for 1 hour, combine it with the other four flavors such as Peucedanum chinensis (Tinglizi wrapped in fried), add water to boil twice, add 8 times the amount of w...

Embodiment 3

[0025] Prescription: Ephedra 20g, Gypsum 150g, Bitter almond 50g, Peucedanum 20g, Scutellaria baicalensis 60g, Perilla (fried) 90g, Tinglizi 60g, Zhuru 90g.

[0026] Preparation method: take the above eight flavors, take ephedra and crush it into coarse powder, add 3 times the amount of acidic aqueous solution with a pH value of 3.5 to soak for 2 days, then carry out percolation extraction, collect 20 times the percolation liquid, adjust the pH to 6, filter and concentrate for later use; crush bitter almonds Then quickly inactivate the enzyme with circulating steam for 60 minutes, take the bitter almonds after the enzyme inactivation, add 1 times the amount of 10% ethanol to soak for 2 days, and then carry out percolation, collect 3 times the percolation liquid, filter and concentrate, and set aside. Add water to the gypsum and boil it for 1 hour, combine it with the other four flavors such as Peucedanum chinensis (Tinglizi wrapped in fried), add water to boil twice, add 6 time...

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Abstract

The invention discloses a method for preparing an infantile lung clearing and phlegm eliminating preparation, which comprises the following steps of: a, weighing ephedra, gypsum, bitter almond, whiteflower hogfennel root, baical skullcap root, perilla fruit powder, pepperweed seed and bamboo shavings; b, soaking ephedra coarse powder in acidic aqueous solution, and percolating for extracting; c, crushing bitter almond, inactivating enzyme, and extracting by low-degree alcoholic solution; d, decocting gypsum, adding other components, extracting in water, mixing with ephedra concentrating solution and bitter almond concentrating solution, and concentrating to form extract; and e, adding an excipient and auxiliary materials, and preparing by the conventional method of preparations to obtain a pharmaceutically-acceptable preparation. By the method, the extraction rate of ephedrine and amygdalin can be improved, the curative effect of medicines can be improved, and the quality stability ofproducts can be improved simultaneously.

Description

technical field [0001] The invention relates to a preparation method of a pharmaceutical preparation, in particular to a preparation method of a medicinal preparation for clearing away heat and resolving phlegm, relieving cough and relieving asthma. technical background [0002] The children's clearing lung and reducing phlegm preparation is developed on the basis of Maxing Shigan Decoction in "Treatise on Febrile Diseases", which is a famous Chinese medicine classic in my country. Lizizi and Zhuru are composed of eight herbs; it has the effect of clearing away heat and resolving phlegm, relieving cough and relieving asthma. It has very good curative effect on shortness of breath, cough, phlegm and wheezing, and throat noise caused by lung heat and cold in children. It is a therapeutic and One of the effective prescriptions to prevent influenza A virus. At present, when preparing the preparation, the gypsum in the above eight flavors is usually decocted with water for 1 hour,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61P11/00A61P11/10A61K33/06
Inventor 陈钟卢树杰陈浩达
Owner SHINEWAY PHARMA GRP LTD