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Sequential and repeated application of four or more HIV (human immunodeficiency virus) vector gene vaccines

A vaccine and AIDS technology, applied in the field of biomedicine, can solve the problems of restricting the repeated application of vaccines, and achieve the effect of maintaining a high level for a long time, good specific immune response, and prolonging time.

Active Publication Date: 2013-07-24
STATION OF VIRUS PREVENTION & CONTROL CHINA DISEASES PREVENTION & CONTROL CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Carrier vaccines can induce a good cellular immune response, but the immunogenicity of the carrier itself greatly limits the repeated application of the vaccine, so it is necessary to sequentially apply a variety of carrier vaccines that can well induce HIV-specific immune responses to achieve The effect of being able to treat multiple times in the patient's body

Method used

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  • Sequential and repeated application of four or more HIV (human immunodeficiency virus) vector gene vaccines
  • Sequential and repeated application of four or more HIV (human immunodeficiency virus) vector gene vaccines

Examples

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Embodiment Construction

[0019] HIV Vaccine Sequential and Repeated Immunization Experiments in Rhesus Monkeys

[0020] 1. Vaccine Immunization and Grouping

[0021] Eight adult rhesus monkeys were randomly divided into 3 groups. The 2 monkeys in the first group were the PBS control group. At all the same immunization time points as the experimental group, 1ml sterile PBS was injected intramuscularly; the 5 monkeys in the second group were the four vaccine immunization groups. , first immunized twice with DNA at 0 weeks and 2 weeks (the DNA vaccine used is a eukaryotic expression plasmid expressing the codon-optimized gag gene, which is in the prior patent application submitted by the applicant in 2006 with the application number 200610098946.1 The constructed pVR-mod.gag was produced by Benyuan Zhengyang Gene Technology Co., Ltd.), and then immunized with the same dose of adenovirus vaccine rAd5-gag (rAd5-gag is E1, Replication-defective recombinant type 5 adenovirus with E3 deletion, the expressed ...

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Abstract

The present invention provides a combined AIDS vaccine for preventing and / or treating AIDS, which consists of four or more different vector AIDS vaccines, wherein HIV protein gene comprised in the different AIDS vaccines may be the same. A use method of the vaccine comprises inoculation of one AIDS vaccine each time, wherein inoculation of each vaccine may be continuously performed twice, and after sequential application of the four or more vector vaccines, repeated sequential application of the vector vaccines may be performed.

Description

technical field [0001] The invention belongs to the field of biomedicine. The invention relates to an immunization strategy for sequential and repeated application of four or more HIV vector gene vaccines. The specific application will not be limited to the four vaccines used in this previous study. Background technique [0002] Human immunodeficiency virus (Human immunodeficiency virus, HIV) belongs to the human lentivirus group in the genus Lentivirus of the Retroviridae family. It is the pathogen of acquired immunodeficiency syndrome (AIDS) or AIDS. Identification. AIDS is considered to be the world's largest infectious disease that directly threatens human health, and has become an important public health problem worldwide. The 2009 Global AIDS Epidemic Trend Report jointly issued by UNAIDS and the World Health Organization shows that there are about 33.4 million HIV-infected people in the world, of which 2.7 million were newly infected in 2008, and 2 million people d...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/21A61K48/00A61P31/18
CPCA61K48/00A61K39/21A61K39/12A61K2039/523A61K2039/5256A61K2039/5258A61K2039/53A61K2039/545A61P31/18C12N2710/10343C12N2710/24143C12N2740/16234C12N2760/18843
Inventor 曾毅冯霞余双庆杨玲李泽林孔维于湘晖
Owner STATION OF VIRUS PREVENTION & CONTROL CHINA DISEASES PREVENTION & CONTROL CENT