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Medical anti-adhesion material and preparation method thereof

An anti-adhesion, medical technology, applied in medical science, surgery, etc., can solve problems such as poor adhesion and inconvenient operation, and achieve the effects of reducing adhesion, reducing inter-tissue adhesion, anticoagulation and lubrication isolation

Inactive Publication Date: 2015-07-08
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, film-type materials also have disadvantages such as inconvenient operation, poor adhesion, and the need for additional fixing.

Method used

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  • Medical anti-adhesion material and preparation method thereof
  • Medical anti-adhesion material and preparation method thereof
  • Medical anti-adhesion material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1, PLLA- b -Synthesis of PEG

[0030] Catalyzed by stannous octoate (Sn(Oct) 2 ), the amphiphilic block copolymer PLLA- b -PEG. The specific steps are as follows: add 0.1g PEG-OH and 0.5g LLA to the dry reaction bottle, vacuumize and remove oxygen, fill with argon, add 2.55ml Sn(Oct) 2 Toluene solution (concentration of 0.982mol / L) and 5mL toluene were used as solvent, and the product PLLA- b -PEG, see synthetic route figure 2 . The composition and molecular weight of the copolymer can be adjusted by adjusting the amount of LLA added and the molecular weight of PEG.

Embodiment 2

[0031] Embodiment 2, PLGA- b -Synthesis of PEG

[0032] at Sn(Oct) 2 Under the catalysis, the amphiphilic block copolymer PLGA- b -PEG. The specific steps are as follows: add 0.1g PEG-OH, 0.5gGA and 0.5g LLA to the dry reaction bottle, vacuumize and remove oxygen, fill with argon, add 2.55ml Sn(Oct) 2 The product PLGA- b -PEG, see synthetic route image 3 . The composition and molecular weight of the copolymer can be adjusted by adjusting the addition amount of LLA and GA and the molecular weight of PEG.

Embodiment 3

[0033] The synthesis of embodiment 3, PCL-PEG-PCL

[0034] at Sn(Oct) 2 The amphiphilic triblock copolymer PCL-PEG-PCL was obtained by CL ring-opening polymerization initiated by catalyzed polyethylene glycol with hydroxyl groups at both ends (HO-PEG-OH). The specific steps are as follows: add 0.1g HO-PEG-OH and 0.5g CL to the dry reaction bottle, vacuumize and deoxygenate, fill with argon, add 2.55ml Sn(Oct) 2 Toluene solution (concentration: 0.982mol / L) and 5mL toluene were used as solvent, and the product PCL-PEG-PCL was obtained after reaction at 110°C for 48 hours. The synthetic route is shown in Figure 4 . The composition and molecular weight of the copolymer can be adjusted by adjusting the amount of CL added and the molecular weight of PEG.

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Abstract

The invention discloses a medical anti-adhesion material and a preparation method thereof. The medical anti-adhesion material is a microsphere, gel or a composite material of microsphere / gel which are prepared from copolymer of aliphatic polyester and polyethylene glycol as a raw material. The medical anti-adhesion material has the advantages of good biocompatibility, adjustable tissue adhesivity and degradation speed, high mechanical strength and good toughness, and the material can be compounded with a plurality of medicines for use, thus meeting various clinical demands. The medical anti-adhesion material provided by the invention can adapt to irregular shape of wound positions and fully covers a wound surface; and when in use, the material is simple in operation and convenient in use.

Description

technical field [0001] The invention relates to a medical anti-adhesion material and a preparation method thereof. Background technique [0002] Adhesion after surgery has always been one of the problems to be solved urgently in medicine, and most operations involve the problem of adhesion between tissues. Adhesions are abnormal structures where fibrous bands of connective tissue join together with adjacent tissues or organs and can range in size from a thin film to a dense vascular scar. It will not only cause serious complications, such as intestinal obstruction, epilepsy, secondary recurrent laryngeal nerve injury, etc., but also increase the difficulty of reoperation. Studies have shown that the root cause of adhesion is the proliferation of fibroblasts. At present, the "short-term barrier method" is usually used clinically to solve the problem of tissue adhesion, that is, the method of implanting an isolation material at a site prone to adhesion after surgery. [000...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61L31/16A61L31/14C08G63/664C08J3/16C08J3/075
Inventor 龙飞虎石旭东甘志华
Owner INST OF CHEM CHINESE ACAD OF SCI
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