Construction method of rheumatoid arthritis atlas model and its atlas model
A technology for constructing methods and atlas models, applied in the field of rheumatoid arthritis information, which can solve problems such as lack of research results and technical information
Active Publication Date: 2011-11-30
戴勇 +1
View PDF0 Cites 6 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
[0004] However, there are no specific research results and technical information on how to combine metabolomics methods for comprehensive analysis of rheumatoid arthritis.
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment Construction
[0023] The specific implementation manners of the present invention will be described in detail below in conjunction with the accompanying drawings.
[0024] An embodiment of the present invention is a method for constructing a rheumatoid arthritis map model, which includes the following steps.
[0025] A1. Obtain 3ml of venous blood that has been separated from the human body from the test group and the reference group, and let it stand for 25 to 30 minutes; for example, let it stand for 25 to 28 minutes, and the standing time must be long enough to allow various molecules in the isolated blood to Stable and layered. For example, the test group may include a plurality of different RA patients' detached venous blood, and similarly, the reference group may include a plurality of different healthy volunteers' detached venous blood. For example, the test group includes isolated blood from 50 to 100 or more RA patients, and for another example, the reference group includes isolat...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More Abstract
The invention relates to a rheumatoid arthritis spectrum model and a construction method thereof. The construction method comprises the following steps of: acquiring 3ml of venous blood separated from human body in an experimental group and a reference group and standing for 25-30 minutes; centrifuging for 8-10 minutes; respectively absorbing 600mul of supernate from the height position which is three fourths of the liquid level and storing at low temperature; respectively absorbing 200mul of supernate from the height position which is three fourths of the liquid level; adding 200mul of heavy water with D2O of 99.5 percent and mixing to obtain a mixed solution; acquiring a spectrogram of a one-dimensional hydrogen spectrum of the mixed solution; carrying our Fourier transform, phase adjustment, baseline correction, calibration and integration processing to obtain rheumatoid arthritis spectrums of supernate; establishing a main component analysis model and a partial least squares method model for each rheumatoid arthritis spectrum of the supernate in the experimental group and the reference group and carrying out multiple statistical analysis; and establishing the rheumatoid arthritis spectrum model according to the analysis result of multiple statistical analysis.
Description
【Technical field】 [0001] The present invention relates to an acquisition of rheumatoid arthritis information as an intermediate result, in particular to a method for constructing a rheumatoid arthritis map model, and a rheumatoid arthritis map model constructed by the construction method. 【Background technique】 [0002] Rheumatoid arthritis (RA) is a common systemic inflammatory autoimmune disease with a long course and many complications. Although clinically, the phases of remission and activity appear alternately, but they all eventually lead to bone and joint damage to the loss of the patient's mobility. Only through early intervention and treatment can the disease be effectively controlled and its development delayed. However, after years of research, its molecular pathogenesis is still not very clear. This brings great challenges to the early diagnosis and treatment of diseases. At present, clinical diagnosis of RA mostly relies on clinical symptoms and detection of ...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More Patent Type & Authority Applications(China)
IPC IPC(8): G01N24/08G01N1/28
Inventor 戴勇欧阳昕
Owner 戴勇