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Oil suspension agent of benzimidazole medicine

A technology of benzimidazole and medicinal oil, applied in the field of antiparasitic drugs, can solve problems such as no good clinical effect, widespread spread of echinococcosis, unsuitable surgery for cases, etc., to improve bioavailability and reduce dosage and course of treatment, the effect of reducing the cost of treatment

Active Publication Date: 2013-02-13
STATION OF VIRUS PREVENTION & CONTROL CHINA DISEASES PREVENTION & CONTROL CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Before the 1970s, the main treatment for echinococcosis was surgical resection, but there were problems such as recurrence after surgery, leakage of a large number of protoscolees during surgery, causing widespread dissemination of echinococcosis, and some cases were not suitable for surgery.
However, such a large dose does not produce a good clinical effect. The results of clinical research at home and abroad show that the therapeutic effect of albendazole is better than that of mebendazole, and the cure rate is 30-40%.

Method used

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  • Oil suspension agent of benzimidazole medicine
  • Oil suspension agent of benzimidazole medicine
  • Oil suspension agent of benzimidazole medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 mebendazole oleic acid suspension

[0024] Weigh 0.5g of mebendazole, add Span800.5ml, peanut oil 10ml, soybean oil 10ml respectively, add oleic acid to 100ml, stir in a ball mill for one hour, and prepare mebendazole oleic acid suspension, the concentration of mebendazole 5mg / ml.

Embodiment 2

[0025] The preparation of embodiment 2 mebendazole soybean oil suspension

[0026] Weigh 0.5g of mebendazole, add Tween800.5ml, olive oil 10ml, oleic acid 10ml respectively, add soybean oil to 100ml, stir in a ball mill for one hour, and prepare mebendazole soybean oil suspension, the content of mebendazole The concentration is 5mg / ml.

Embodiment 3

[0027] The preparation of embodiment 3 albendazole oleic acid suspension

[0028] Weigh 0.5g albendazole, add Span800.5ml, peanut oil 10ml, soybean oil 10ml respectively, add oleic acid to 100ml, stir in a ball mill for one hour, and prepare albendazole oleic acid suspension, albendazole The concentration is 5mg / ml.

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Abstract

The invention provides a new formulation, namely oil suspension agent, of antiparasitic benzimidazole medicine. The oil suspension agent comprises benzimidazole medicine, a liquid grease, a suspending agent and a wetting agent. The oil suspension agent of benzimidazole medicine provided by the invention is used for treating echinococcosis and other parasitic diseases and can be used for increasing blood concentration and improving curative effects. The oil suspension agent has simple preparation method, good stability and easiness in popularization.

Description

field of invention [0001] The invention relates to antiparasitic drugs, in particular to the dosage form reform of benzimidazole drugs, more specifically to the oil suspension of benzimidazole drugs. Background technique [0002] Hydatid disease is a global human and zoonotic disease, and it is a parasitic disease that seriously damages the health of humans and livestock. Echinococcosis is a disease caused by the parasitic larvae of Echinococcus tapeworm in the intermediate host. The main types of echinococcosis in my country are cystic echinococcosis (echinococcosis granulosus) and alveolar echinococcosis (alveolar echinococcosis), which are caused by the larvae of Echinococcus granulosus (Echinococcus granulosus). ) and Echinococcus multilocularis larvae (alveolar coccus) parasitic on human and animal tissues and organs. The development of echinococcosis in the body is slow, mainly based on chronic consumption, which often makes patients lose their ability to work, especi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/10A61K31/4184A61K47/44A61P33/14
Inventor 张皓冰伍卫平刘丛珊薛剑陶奕姜斌徐莉莉姚俊敏肖树华王立英温爱丹张超威
Owner STATION OF VIRUS PREVENTION & CONTROL CHINA DISEASES PREVENTION & CONTROL CENT