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Ejiao effervescent tablet and preparation method thereof

A technology of effervescent tablets and donkey-hide gelatin, applied in the field of donkey-hide gelatin effervescent tablets and its preparation, can solve the problems of bad taste, difficult to remove the fishy smell of donkey-hide gelatin, bitterness, sticking, etc., and achieve rapid disintegration, stable products, and production The effect of simple process

Inactive Publication Date: 2011-12-21
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, donkey-hide gelatin in the gelatinous block preparation needs to be hydrated when taking it, and it is difficult to remove the fishy and bitter taste of donkey-hide gelatin; although the donkey-hide gelatin powder reported in the data has a fast melting speed, it still has a sticking phenomenon and has a bad taste. Shortcomings

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Mix 50 parts of donkey-hide gelatin and 50 parts of diluent evenly according to the number of parts by mass and then divide it into two equal parts of A and B. Lactose, add 2.4 parts of organic acid to part A and prepare acidic granules with 3 parts of binder, the organic acid is citric acid, add 2.16 parts of sodium bicarbonate and 0.8 parts of sweetener to part B Prepare alkaline granules with 3 parts of binding agent afterward, described sweetener is protein sugar, and described binding agent is the mixture of polyvinylpyrrolidone (PVP) and the aqueous ethanol solution that volume fraction is 75%, the quality of PVP in the mixture The fraction is 10%. After mixing acidic granules and basic granules, dry them in a constant temperature drying oven. The drying temperature is 50°C, and the drying time is 2 hours. After drying, granules are sized, and then 3 parts of lubricant are added And use a single-punch tablet machine to compress the tablet to obtain effervescent do...

Embodiment 2

[0021] Mix 150 parts of donkey-hide gelatin with 50 parts of diluent evenly according to the number of parts by mass and then divide it into two equal parts of A and B. Lactose, after adding 4.8 parts of organic acid to part A, prepare acidic granules with 5 parts of binder, the organic acid is citric acid, add 4.32 parts of sodium bicarbonate and 0.8 part of sweetener to part B Prepare alkaline granules with 5 parts of binding agent afterward, described sweetener is protein sugar, and described binding agent is the mixture of polyvinylpyrrolidone (PVP) and the aqueous ethanol solution that volume fraction is 75%, the quality of PVP in the mixture The fraction is 10%. After mixing the acidic granules and basic granules, dry them in a constant temperature drying oven. The drying temperature is 50°C, and the drying time is 2 hours. After drying, granules are sized, and then 6 parts of lubricant are added And use a single-punch tablet machine to compress the tablet to obtain effe...

Embodiment 3

[0024] Mix 150 parts of donkey-hide gelatin and 150 parts of diluent evenly by mass parts and divide into two equal parts of A and B. Lactose, add 9.6 parts of organic acid to part A and prepare acidic granules with 8 parts of binder, the organic acid is citric acid, add 8.64 parts of sodium bicarbonate and 1.0 part of sweetener to part B Prepare alkaline granules with 8 parts of binding agent afterward, described sweetener is protein sugar, and described binding agent is the mixture of polyvinylpyrrolidone (PVP) and the aqueous ethanol solution that volume fraction is 75%, the quality of PVP in the mixture The fraction is 10%. After mixing the acidic granules and basic granules, dry them in a constant temperature drying oven. The drying temperature is 50°C, and the drying time is 2 hours. After drying, granules are sized, and then 13 parts of lubricant are added And use a single-punch tablet machine to compress the tablet to obtain effervescent donkey-hide gelatin tablets, an...

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Abstract

The invention provides a donkey-hide gelatin effervescent tablet and a preparation method thereof: mix 50-150 parts of donkey-hide gelatin with 50-150 parts of diluent according to the mass parts, divide it into two equal parts A and B, add 0.6- After 9.6 parts of organic acid, use 3-9 parts of binder to prepare acidic granules, add 0.54-8.64 parts of sodium bicarbonate and 0.8-1.0 parts of sweetener to B part, and then use 3-9 parts of binder Prepare the alkaline granules, mix the acidic granules and the basic granules, dry them, adjust the granules after drying, add 3-13 parts of lubricant and compress them with a single-punch tablet machine to obtain effervescent donkey-hide gelatin tablets. The prepared donkey-hide gelatin effervescent tablet not only maintains the quality of the original donkey-hide gelatin but also improves the taste.

Description

technical field [0001] The invention belongs to the field of preparation of donkey-hide gelatin tablets, in particular to an effervescent donkey-hide gelatin tablet and a preparation method thereof. Background technique [0002] Donkey-hide gelatin (colla CoriiAsini) is a gelatin block made from the skin of an equine animal donkey after depilation. The main component of donkey-hide gelatin is collagen. Clinically, donkey-hide gelatin is often used to treat blood deficiency and chlorosis, dizziness, palpitations, labor cough, hemoptysis, and hematemesis. In addition, donkey-hide gelatin can also be used in the food field and is a good nourishment. However, donkey-hide gelatin in the gelatinous block preparation needs to be hydrated when taking it, and it is difficult to remove the fishy and bitter taste of donkey-hide gelatin; although the donkey-hide gelatin powder reported in the data has a fast melting speed, it still has a sticking phenomenon and has a bad taste. Shortc...

Claims

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Application Information

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IPC IPC(8): A61K35/36A61K9/46A23L1/29A61P7/06A61P7/04A61P9/06A23L33/00
Inventor 毛跟年宋怡敏许牡丹
Owner SHAANXI UNIV OF SCI & TECH
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