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Nanoparticle contrast agents for diagnostic imaging

A technology for nanoparticles and diagnostic agents, applied in the field of preparing the nanoparticles, can solve the problems of insufficient understanding of the effect of the clearance rate of the nanoparticle agents and the like

Inactive Publication Date: 2012-01-25
GENERAL ELECTRIC CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of particle size, structure, and surface properties on in vivo biodistribution and clearance of nanoparticles is not well understood

Method used

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  • Nanoparticle contrast agents for diagnostic imaging
  • Nanoparticle contrast agents for diagnostic imaging
  • Nanoparticle contrast agents for diagnostic imaging

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0073] The practice of this invention can be more fully understood by the following examples, which are provided herein for illustration only and should not be construed as limiting the invention in any way.

[0074] Abbreviations used in the Examples section are explained as follows: "mg": milligram; "mL": milliliter; "mg / mL": milligram per milliliter; "mmol": millimole; "μL": microliter; "LC" : liquid chromatography; "DLS": dynamic light scattering; "DI": deionized water; "ICP": inductively coupled plasma.

[0075] Unless otherwise mentioned, all reagent grade chemicals were used as received and Millipore water was used in all aqueous preparations.

[0076] Synthesis of tantalum oxide-based nanoparticles

[0077] Step 1: Synthesis of N,N-dimethyl-3-sulfo-N-(3-(trimethoxysilyl)propyl)propan-1-ammonium

[0078] Toluene (anhydrous, 250 mL), N,N-dimethylaminotrimethoxysilane (25 g, 121 mmol) and 1,3-propanesultone (13.4 g, 110 mmol) were added to a 500 mL round bottom containi...

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Abstract

Nanoparticles (10) functionalized with at least one zwitterionic moiety, and compositions comprising said nanoparticles are provided. The nanoparticles (10) have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle (10) comprises a core (20), having a core surface (30) essentially free of silica, and a shell (40) attached to the core surface (30). The shell (40) comprises at least one silane- functionalized zwitterionic moiety. Further, methods of making said nanoparticles and methods of their use as diagnostic agents are provided.

Description

Background of the invention [0001] The present application generally relates to contrast agents for diagnostic imaging (eg, for X-ray / computed tomography (CT) or magnetic resonance imaging (MRI)). More specifically, the present application relates to nanoparticle-based contrast agents and methods of making and using these agents. [0002] Almost all clinically approved diagnostic contrast agents are based on small molecules. Iodinated aromatic compounds have been used as standard X-ray or CT contrast agents, while Gd-chelates are used in magnetic resonance imaging. Although commonly used in diagnostic imaging, small molecule contrast agents can have certain disadvantages, such as leakage from vessel walls, resulting in short blood circulation times, lower sensitivity, high viscosity, and high osmolality. These compounds are generally associated with renal complications in some patient populations. Such small molecule agents are known to clear rapidly from the body, which li...

Claims

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Application Information

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IPC IPC(8): A61K49/04A61K49/18
CPCA61K49/0428A61K49/1848B82Y5/00B82Y15/00
Inventor R·E·科尔博恩P·J·小博尼塔蒂巴斯A·S·托里斯M·E·马里诺M·D·巴茨A·库尔卡尼B·C·贝尔斯B·A·海
Owner GENERAL ELECTRIC CO