Bone cement composition, bone cement composition kit, and method for forming bone cement cured body

A technology of bone cement and composition, applied in the directions of bone implants, surgical adhesives, prostheses, etc., can solve the problems of lack of osseointegration, relaxation of artificial joints and bones, and lack of biological activity, so as to improve work Efficiency, shortening dough time, effect of shortening dough time

Inactive Publication Date: 2014-06-04
KYOTO UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In recent years, as PMMA-based bone cement compositions, the PMMA-based bone cement compositions used so far have been biocompatible, but not bioactive, that is, they do not have osseointegration properties that combine with bone. Therefore, especially when used as an adhesive for fixing the artificial joint and the surrounding bone, there is a problem that the adhesive is isolated from the surrounding bone due to a long period of time from the application, thereby causing a gap between the artificial joint and the bone. Therefore, in order to solve this problem, a composition in which titanium dioxide particles are added has been proposed for the purpose of imparting bioactivity (for example, refer to Patent Document 1).
[0006] However, with the bone cement composition used so far, in many cases, especially in surgery, there is a problem that, during the aforementioned handling operations, for example, adhesion to latex surgical gloves that are worn on the hand, etc. ills

Method used

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  • Bone cement composition, bone cement composition kit, and method for forming bone cement cured body
  • Bone cement composition, bone cement composition kit, and method for forming bone cement cured body
  • Bone cement composition, bone cement composition kit, and method for forming bone cement cured body

Examples

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Embodiment

[0210] Specific examples of the present invention will be described below, but the present invention is not limited to these examples.

[0211] In addition, in the following examples and comparative examples, the average particle diameter of the (meth)acrylate polymer large particle diameter and the average particle diameter of the (meth)acrylate polymer small particle diameter (primary particle diameter) and the method of measuring the average particle diameter of aggregates of (meth)acrylate polymer particles with small particle diameters are as follows.

[0212] (Measurement method of average particle diameter of (meth)acrylate polymer large particle diameter and small particle diameter particle)

[0213] As the average particle diameter, the median diameter measured by a laser diffraction / scattering particle size distribution meter was measured. As the laser diffraction / scattering particle size distribution meter, a particle size distribution measuring device "Microtrac" (...

manufacture example 1

[0228] (Preparation of titanic acid slurry)

[0229] The orthotitanic acid in wet cake state is obtained by neutralizing the titanium tetrachloride aqueous solution with ammonia water, and then filtering and washing with water. Thereafter, the obtained orthotitanic acid and pure water in the state of wet cake were fed into a mixer, stirred and mixed thoroughly, so as to obtain orthotitanic acid slurry.

[0230] (wet crushing process)

[0231] Using Dyno-mill "DYNO-MILL" (manufactured by SHINMARU ENTERPRISES CORPORATION), fill 480mL of titanium dioxide beads (manufactured by Toyama Ceramic K.K.) with an average particle diameter of 0.6mm into the interior of the Dyno-mill main body with a volume of about 600mL, and flow at a flow rate of 160mL / The obtained orthotitanic acid slurry is fed into the obtained orthotitanic acid slurry under the condition of 10 minutes, and the rotating blade arranged inside the main body is rotated, thereby performing Dyno grinding treatment, ther...

manufacture example 2

[0246] By the same method as in Production Example 1 of titanium dioxide particles, a median particle size of 3.1 μm and a BET specific surface area of ​​2.1 μm were obtained. 2 / g of titanium dioxide particles (hereinafter also referred to as "titanium dioxide particles (b)").

[0247] The obtained titanium dioxide particles (b) were confirmed to be rutile-type titanium dioxide particles as a result of powder X-ray diffraction using a powder X-ray diffractometer "RINT1200" (manufactured by Rigaku Corporation), and also confirmed by scanning electron microscope "S-3200N" (manufactured by Hitachi, Ltd.) As a result of observation, the shape was confirmed to be spherical.

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PUM

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Abstract

The invention has as its objects the provision of a bone cement composition, a bone cement composition kit for obtaining the bone cement composition, and a production method of a bone cement hardened material, which are short in doughing time that is a time required to become a state in which a good handling operation can be conducted, and have consequently capable of achieving a high working efficiency by shortening the time required before the handling operation is started. The bone cement composition of the invention contains large-diameter (meth)acrylate polymer particles having an average particle diameter of 10 to 60 µm, small-diameter (meth)acrylate polymer particles having an average particle diameter of 0.1 to 2.0 µm, a (meth)acrylate monomer and a polymerization initiator, wherein the content of the small-diameter (meth)acrylate polymer particles is 5 to 30% by mass based on the total mass of the small-diameter (meth)acrylate polymer particles and the large-diameter (meth)acrylate polymer particles.

Description

technical field [0001] The present invention relates to a bone cement composition, a bone cement composition kit and a method for manufacturing a bone cement solidified body. Background technique [0002] Hitherto, bone cement compositions have been widely used all over the world as filling agents for bone defects or as adhesives for fixing metal artificial joints such as artificial hip joints and surrounding bones. , the most commonly used polymethyl methacrylate (PMMA) bone cement composition. [0003] PMMA series bone cement composition generally contains polymethyl methacrylate, and as the methyl methacrylate monomer of polymerizable monomer and polymerization initiator, it passes (meth) methyl acrylate monomer in polymethacrylic acid Polymerization in the presence of methyl esters increases the viscosity slowly, and finally forms a cured body. [0004] In recent years, as PMMA-based bone cement compositions, the PMMA-based bone cement compositions used so far have bee...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61L27/00
CPCA61L24/06A61L24/0089A61L2430/02C08L33/06A61F2/28A61L24/02A61L24/04A61L2400/00
Inventor中村孝志后藤公志涩谷武宏上田泰行吹田德雄今村匡志西井启晃
OwnerKYOTO UNIV