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Extraction process of effective ingredients from cordyceps mycelia

A technology of Cordyceps mycelium and active ingredients, which is applied in the direction of medical preparations containing active ingredients, organic active ingredients, plant/algae/fungus/moss ingredients, etc., which can solve the problem of easy damage, low extraction efficiency, and easy damage problems such as improving production efficiency, reducing production costs, and reducing the use of organic solvents

Active Publication Date: 2013-05-01
吉林省美罗国际生物科技集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Cordycepin is fat-soluble and is easily destroyed by heat. The conventional extraction method is to use 10 times the amount of water to heat reflux at 80°C for 3 times for 90 minutes each time, but the extraction efficiency is not high.
If the temperature exceeds 80 degrees, it will be easily damaged

Method used

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  • Extraction process of effective ingredients from cordyceps mycelia
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  • Extraction process of effective ingredients from cordyceps mycelia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 Extraction of Cordyceps Mycelia Active Components

[0043] Such as figure 1 The extraction process flow chart of the shown Cordyceps mycelium active ingredient:

[0044] 1. The freeze-dried powder of Cordyceps mycelium is crushed into 20-40 mesh granules, weighed and put into the extraction kettle. It is required that the particles are uniform and the moisture content is not more than 7%.

[0045] 2. The carbon dioxide fluid is extracted for 3 hours, the pressure is 21 MPa, the temperature is 45 degrees, the amount of ethanol aqueous solution used as entrainer is 0.5 times the amount of mycelium, and the mass percentage concentration of ethanol in the ethanol aqueous solution can be 60-95%, which is more suitable The concentration is 95%.

[0046] 3. During the extraction, the separation tank is separated, the separation tank I discharges the extract, and the separation tank II discharges ethanol. Ethanol is recovered, and the residual extract is mixed wit...

Embodiment 2

[0058] Example 2 Extraction of Cordyceps Mycelia Active Components

[0059] 1. The freeze-dried powder of Cordyceps mycelium is crushed into 20-40 mesh particles, the amount of material is weighed, the same amount as in Example 1, and put into the extraction kettle. It is required that the particles are uniform and the moisture content is not more than 7%.

[0060] 2. Carbon dioxide fluid extraction for 2-3 hours, the pressure is controlled at 18-26MPa, the temperature is controlled at 35-50 degrees, the amount of entraining agent ethanol aqueous solution is 0.5-3 times the amount of mycelia, and the mass percentage concentration of ethanol in the ethanol aqueous solution It can be 60-95%, a more suitable concentration is 95%.

[0061] 3. During the extraction, the separation tank is separated, the separation tank I discharges the extract, and the separation tank II discharges ethanol. Ethanol is recovered, and the residual extract is mixed with the extract of the separation...

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Abstract

The invention relates to extraction of effective ingredients from traditional Chinese medicines, in particular to an extraction process of effective ingredients from cordyceps mycelia. Aiming at technical problems to be solved, the extraction process provided by the invention comprises the following steps of: firstly, carrying out liquid fermentation on cordyceps mycelia, and carrying out solid-liquid separation on the fermentation liquid; then, drying the mycelia by a freeze-drying method; crushing the dried cordyceps mycelia into powder of 20-40 meshes; carrying out supercritical extractionwith carbon dioxide to obtain cordycepin and other fat-soluble components which are easily damaged by heat; carrying out water extraction and alcohol precipitation on the cordyceps mycelia after supercritical extraction to obtain cordyceps polysaccharides; and mixing supercritical extracts and the extracts obtained by water extraction and alcohol precipitation according to an extraction ratio to obtain bran-new component extracts of cordyceps mycelia. The extraction process provided by the invention greatly saves the resources and improves the content and efficacy of effective ingredients.

Description

technical field [0001] The invention relates to the extraction of effective components of Chinese medicinal materials, in particular to an extraction process of effective components of Cordyceps mycelium. Background technique [0002] 1. Cordyceps: [0003] The Chinese name is Cordyceps sinensis, and the English name is plantworms; entomophyte, scientific name (Latin name) is Cordyceps sinensis. [0004] Definition: Bat moth larvae are infected by Cordyceps sinensis. After death, the dead body, tissue and mycelium form a hard pseudosclerotia, which remains unchanged for several months in the low-temperature and dry soil in winter (winter worm) , when the temperature and humidity are suitable in summer, rod-shaped fruiting bodies (ascus) grow from the sclerotia and are exposed to the ground (sinensis). It is a traditional Chinese medicinal material. The real Cordyceps sinensis is wild, and it is mainly produced in the alpine regions and snow-capped grasslands of Qinghai, T...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/068A61K31/7076A61K31/715A61P1/14A61P11/00A61P15/08A61P31/04A61P31/12A61P35/00A61P37/04
Inventor 周伯扬
Owner 吉林省美罗国际生物科技集团股份有限公司
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