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Dripping core pill preparation with effect of relieving sore throat and preparation method thereof

A technology of action and sound, applied in the field of pharmaceuticals, can solve the problems of large amount of excipients, slow dissolution, low drug content, etc.

Active Publication Date: 2013-12-25
WUXI JIYU SHANHE PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Dropping pill preparations dissolve faster than pills and are easy to absorb, but their drug content is too low and the amount of excipients is large, which increases the dosage; while the disadvantage of concentrated pills is that they dissolve slowly and have low bioavailability

Method used

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  • Dripping core pill preparation with effect of relieving sore throat and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The volatile oil extracted from Rhizoma Chuanxiong, Forsythia, and Peppermint, mixed and dissolved with menthol for later use; Rhubarb, Fritillaria, and Campanulaceae were crushed into coarse powder, 60% ethanol was used as a solvent, percolated, and the ethanol was recovered under reduced pressure from the percolated liquid until it was completely dry. Ethanol smell, get thick paste with alcohol extraction; add water to decoct Panda Hai, cicada slough, myrobalan meat, catechu, licorice three times, the three decoction times are: 1.5 hours, 1.5 hours, 1 hour, filter, combine the filtrate, Stand still, filter, concentrate the filtrate under reduced pressure to clear paste, combine with alcohol extraction paste, spray dry (inlet air temperature 210-230°C, outlet air temperature 75-85°C) to obtain fine powder, add low-substituted hydroxypropyl Cellulose, the addition amount is 7% of the total weight of the mixed powder obtained by mixing the extract powder and low-substitut...

Embodiment 2

[0050]The volatile oil extracted from Rhizoma Chuanxiong, Forsythia, and Peppermint, mixed and dissolved with menthol for later use; Rhubarb, Fritillaria, and Campanulaceae were crushed into coarse powder, 60% ethanol was used as a solvent, percolated, and the ethanol was recovered under reduced pressure from the percolated liquid until it was completely dry. Ethanol smell, get thick paste with alcohol extraction; add water to decoct Panda Hai, cicada slough, myrobalan meat, catechu, licorice three times, the three decoction times are: 1.5 hours, 1.5 hours, 1 hour, filter, combine the filtrate, Stand still, filter, concentrate the filtrate under reduced pressure to clear paste, combine with alcohol extraction paste, spray dry (inlet air temperature 210-230°C, outlet air temperature 75-85°C) to obtain fine powder, add low-substituted hydroxypropyl Cellulose, the addition amount is 7% of the total weight of the mixed powder obtained by mixing the extract powder and low-substitute...

Embodiment 3

[0052] The volatile oil extracted from Rhizoma Chuanxiong, Forsythia, and Peppermint, mixed and dissolved with menthol for later use; Rhubarb, Fritillaria, and Campanulaceae were crushed into coarse powder, 60% ethanol was used as a solvent, percolated, and the ethanol was recovered under reduced pressure from the percolated liquid until it was completely dry. Ethanol smell, get thick paste with alcohol extraction; add water to decoct Panda Hai, cicada slough, myrobalan meat, catechu, licorice three times, the three decoction times are: 1.5 hours, 1.5 hours, 1 hour, filter, combine the filtrate, Stand still, filter, concentrate the filtrate under reduced pressure to clear paste, combine with alcohol extraction paste, spray dry (inlet air temperature 210-230°C, outlet air temperature 75-85°C) to obtain fine powder, add low-substituted hydroxypropyl Cellulose, the addition amount is 7% of the total weight of the mixed powder obtained by mixing the extract powder and low-substitut...

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Abstract

The invention provides a dripping core pill preparation with effect of relieving sore throat and a preparation method thereof. The dripping core pill preparation is prepared from mint, Zhejiang fritillaria bulb, boat-fruited sterculia, periostracum cicadae, rheum officinale, fructus forsythiae, balloonflower root, catechu, fructus chebulae, Ligusticum wallichii, licorice and menthol, and comprises a drug nuclear and a wrapping layer. Compared with an existing product, the dripping core pill preparation of the invention has advantages of fast dissolving, shows advantage of large drug loading of a pill and benefits medicament reservation especially all active substances of a traditional Chinese medicine compound to the most; meanwhile, volatile and fat-soluble components are prepared into dripping pills and wrapped up to effectively prevent loss of active components and realize effects of enhancing curative effect and reducing usage amount of medicament.

Description

technical field [0001] The invention relates to a dripping pill preparation with a sound effect and a preparation method thereof, and is a new dosage form of the Huang's sound preparation, belonging to the technical field of medicines. Background technique [0002] Huang's Xiangsheng Pills are developed according to the nine-generation ancestral secret recipe presented by the chief physician Huang Shennong, a famous old Chinese doctor of throat. , chebula meat, licorice, menthol; its main effect is to clear away wind and heat, resolve phlegm and dissipate stagnation, and relieve throat; it is used for hoarseness, sore throat, dry and burning throat, phlegm in the throat, or cold and heat headache, Or constipation and red urine; acute and chronic laryngitis and other syndromes. [0003] The active ingredients of Huangshi Xiangsheng Pills include fat-soluble ingredients, water-soluble ingredients, and volatile ingredients. Although the simple concentrated pill form can contai...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/8966A61K9/36A61P11/04A61P25/00A61P29/00A61P1/10
Inventor 俞婷范杰周宇
Owner WUXI JIYU SHANHE PHARM CO LTD