Slow-release method for controlling medicine-carrying molecules of lyotopic liquid crystal by using micro electric field
A technology of lyotropic liquid crystals and drug molecules, which is applied in the field of controlled release of drug molecules carried by lyotropic liquid crystals with a micro-electric field, which can solve problems such as limitations and effects of drugs
Inactive Publication Date: 2013-02-27
XI AN JIAOTONG UNIV
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Embodiment 1
[0070] Step 1. Prepare GMO / F127 lyotropic liquid crystal particles by heat treatment and emulsification. Weigh the raw materials according to the mass ratio of F127 and GMO as 10:100, and physically shake them with an oscillator for 5 minutes to mix well. The power of the oscillator is 2300W. The frequency is 90Hz, put it into a water bath with a constant temperature of 55°C, stir it with a magnetic stirrer at a speed of 50 rpm for 10 hours to obtain a coarsely dispersed homogeneity, leave it to incubate for 8 days, and use a cell disruptor intermittent ultrasonic probe Ultrasound 3 times, 20 minutes each time, 10 minutes interval, ultrasonic power 900W, ultrasonic frequency 22KHz, then centrifuge at 10,000 rpm in a centrifuge for 5 minutes, and stand for 24 hours to prepare nano-GMO / F127 lyotropic liquid crystal particles, stored in the dark at 20°C;
[0071] Step 2. Prepare the GMO / F127 lyotropic liquid crystal drug-carrying system. At a constant temperature of 25°C, rotate...
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The invention relates to a slow-release method for controlling medicine-carrying molecules of lyotopic liquid crystal by using a micro electric field. The slow-release method comprises the following steps of: adopting a pulse electric field to carry out controlled release on the carried medicines of the lyotopic liquid crystal; and utilizing the sensitivity of a unique ordered structure consisting of biparental molecules of the lyotopic liquid crystal to the stimulation of external physical factors and the advantage of GMO / F127 lyotopic liquid crystal for carrying the medicines with different polarities and different types, and calculating threshold current density jc equal to sigmaE according to the electric field intensity threshold which is deducted according to the theory and causes the elastic deformation of the liquid crystal, thus designing and finishing pulse controlled release experiment in a mice body and verifying the validity of the slow-release method for controlling the packaged medicines of lyotopic liquid crystal by using the electric field. The method can adopt a quantitative condition to control the release of the medicines and obviously improves the medicine effect and the utilization ratio of the medicines.
Description
technical field [0001] The invention relates to the technical field of controlled release of drugs encapsulated in lyotropic liquid crystals, in particular to a method for controlling the sustained release of drug molecules loaded on lyotropic liquid crystals with a micro-electric field, which can effectively control the release of drugs and improve the utilization rate of drugs. Background technique [0002] In recent years, the controlled release of drugs by microparticle loading is an important research field of drug release technology. At present, the slow-release and controlled-release preparations of drugs mostly control the release rate of drugs by changing the structural characteristics of the carrier. However, the preparation process of drug-loaded particles is complicated, the repeatability between preparation batches is poor, the stability is poor, the organic solvent residue is serious, and the cost is relatively high. High, difficult industrial production and ot...
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IPC IPC(8): A61K47/34A61K47/14A61K9/10A61K38/28A61P3/10
Inventor 张虎勤刘芳娥夏娟娟杜建强吴晓明武亚艳
Owner XI AN JIAOTONG UNIV