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Combination of proantocycidins such as pycnogenol or grape seeds and centella asiatica for the treatment of cardiovascular disorders such as atherosclerosis

A technology of atherosclerosis and Centella asiatica, applied in the direction of cardiovascular system diseases, medical raw materials derived from gymnosperms, medical preparations containing active ingredients, etc., can solve chronic venous diseases and the curative effect has not been well verified And other issues

Inactive Publication Date: 2012-07-11
HORPHAG RES IP PYC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Pycnogenol and Centella asiatica are classified as grade C, indicating that their efficacy in chronic venous disease is not well validated

Method used

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  • Combination of proantocycidins such as pycnogenol or grape seeds and centella asiatica for the treatment of cardiovascular disorders such as atherosclerosis
  • Combination of proantocycidins such as pycnogenol or grape seeds and centella asiatica for the treatment of cardiovascular disorders such as atherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0060] After combined treatment (Pycnogenol 100 mg + TECA 100 mg with or without aspirin 100 mg), the sonophoresis of atherosclerotic plaques in the carotid and femoral arteries was changed by echoreflection. 6-month pilot treatment expectations

[0061] (TECA = Total Triterpenoid Components of Centella Asiatica)

[0062] This study evaluated Pycnogenol Can combined therapy with TECA and aspirin (with or without) reduce platelet aggregation at the branches of the carotid and femoral arteries, reduce local arterial inflammation and intimal plaques caused by inflammation, thereby inhibiting the aggravation of plaque growth and cardiovascular lesions Risk has curative effect.

[0063] Cardiovascular risk has been reduced (hypothesized in this study) by modulating collagen growth of atheromatous plaques in the femoral and carotid arteries. Mainly through echo reflection detection (ultrasound), it was found that the sound permeability of femoral and carotid arteries was signifi...

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Abstract

The invention relates to a preparation for medical purposes and more specifically to a preparation consisting of the combination of proanthocyanidins such as Pycnogenol or grape seeds and Centella asiatica and / or extracts thereof, for use in the prevention or treatment of atherosclerosis.

Description

technical field [0001] The invention relates to a medical preparation, in particular to a compound preparation containing proanthocyanidins (such as pycnogenol or grape seed), centella asiatica and / or its extract for preventing and treating atherosclerosis. Background technique [0002] Diseases that affect the function of the heart are usually classified as heart disease. Specifically, cardiovascular disease refers to diseases involving the heart and blood vessels (arteries and veins) in heart disease. Atherosclerosis is one type of cardiovascular disease. Atherosclerosis is a disease that affects a patient's arteries that carry oxygen-rich blood to the heart and other body organs. The disease involves a process in which fatty substances, cholesterol, waste products produced by cells, and other substances are deposited on the lining of arteries as a hard substance called plaque. This disease usually affects large and medium arteries. [0003] Studies have shown that ath...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61K36/185A61K36/23A61K36/736A61K36/82A61K36/48A61K36/87A61K36/734A61K36/15A61K36/52A61P9/02A61P9/10
CPCA61K36/87A61K31/353A61K36/48A61K36/734A61K36/23A61K36/82A61K36/52A61K36/15A61K36/185A61K36/736A61P9/02A61P9/10A61K2300/00
Inventor 詹尼·贝尔卡罗卡罗琳娜·布尔基维克托·费拉里
Owner HORPHAG RES IP PYC