(6S)-5-methyl tetrahydrofolate crystal form and preparation method thereof

Abstract

The invention discloses a (6S)-5-methyl tetrahydrofolate crystal form and a preparation method thereof. The crystal form is a B-type (6S)-5-methyl calcium tetrahydrofolate crystal form, and diffraction peaks exist at the positions where 2theta angle is 3.2+ / -0.2 and 18.9+ / -0.2 in an X-ray diffraction map of the B-type crystal form; or the crystal form is a C-type (6S)-5-methyl calcium tetrahydrofolate crystal form, and diffraction peaks exist at the positions where 2theta angle is 6.3+ / -0.2 and 19.2+ / -0.2 in the X-ray diffraction map of the C-type crystal form. The B-type (6S)-5-methyl calcium tetrahydrofolate crystal form and the C-type (6S)-5-methyl calcium tetrahydrofolate crystal form disclosed by the invention has the advantages of excellent physicochemical property, good stability, high purity, good repeatability and the like and are suitable for industrial large-scale preparation.

Description

technical field

[0001] The invention belongs to the field of pharmaceutical crystal forms, and in particular relates to two (6S)-5-methyltetrahydrofolate crystal forms and a preparation method and use thereof. Background technique

[0002] (6S)-5-Methyltetrahydrofolate is the main form of folic acid in tissues and blood, and participates in many important biochemical reactions in the body, such as the biosynthesis of purine and thymine. It does not need to go through cumbersome enzymatic steps in the human body and can be directly utilized. In addition, (6S)-5-methyltetrahydrofolate is the only drug among folic acid drugs that can penetrate the blood-brain barrier, and has the effect of preventing and treating Alzheimer's disease (senile dementia), so it has the advantages of other folic acid drugs. Incomparable superiority. It is mainly used in active ingredients of medicines and food additives. It can prevent fetal neural tube defects, arteriosclerosis, and treat megalob...

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