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Mass spectrum imaging platform device and control method

A mass spectrometry imaging and control method technology, applied in the field of industrial automation, can solve the problem of not finding a dedicated imaging platform device, and achieve the effect of ensuring synchronization consistency and pixel accuracy

Active Publication Date: 2014-03-05
TSINGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention provides a mass spectrometry imaging platform based on AFAI technology. At present, no dedicated imaging platform device matching AFAI technology has been found at home and abroad

Method used

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  • Mass spectrum imaging platform device and control method

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Experimental program
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Embodiment 1

[0089] Whole-body tissue slices of mice are used as samples in the experiment of the present invention, and the overall size of the sample is 140×50 mm. The main purpose of the experiment is to conduct clinical research on the distribution of drugs in the entire sample.

[0090] The target drug to be analyzed was catalase (CAT). Mice were administered through their tails. After 20 minutes, mice were euthanized with an overdose of ether and whole mice were frozen in dry ice / isopentane for implementation. Slicing Preparation Use a Leica CM3600 whole-body microtome to slice the mice to obtain 80 μm-thick mouse whole-body tissue slices. Such as Figure 7 Shown is the mouse tissue section diagram of the present invention.

[0091] The mass spectrometer used in the experiment is QTRAP 5500 from AB Company of the United States, and the imaging experiment uses the moving mode of the line scanning method of the present invention. The imaging scan control program module controls the i...

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Abstract

The invention discloses a mass spectrum imaging platform device, which comprises a control box, a high-precision imaging platform, a mass spectrum starting circuit and a serial interface. The high-precision imaging platform comprises a high-precision mobile platform and a horizontal regulating platform; the mass spectrum starting circuit comprises a solid-state relay; the solid-state relay sends a mass spectrum starting signal to the solid-state relay by using a pin of the mass spectrum starting signal in the serial interface; the mass spectrum starting signal is used for controlling the start of a mass spectrometer; the control box carries out communication and control on the high-precision mobile platform; and a computer is connected with the control box through the serial interface. The invention further discloses a mass spectrum imaging control method. Through a design provided by the invention, the problem of remote mass spectrum imaging can be solved.

Description

technical field [0001] The invention relates to the field of industrial automation, in particular to a mass spectrometry imaging platform device cooperating with AFAI mass spectrometry imaging and a mass spectrometry scanning control method cooperating with the mass spectrometry imaging platform. Background technique [0002] Mass spectrometer is a chemical analysis instrument widely used in the world at present, which originates from mass spectrometry. Mass spectrometry is one of the most sensitive, powerful and fast analytical methods at present. Its main purpose is to separate and distinguish the mass-to-charge ratio (ratio of mass to charge, m / e) of sample ions. The basic principle is to make Each component is ionized in the ion source, and various charged ions with different mass-to-charge ratios are produced. After the action of accelerating electric field, focusing electric field, etc., an ion beam is formed and enters the mass analyzer. In the mass analyzer, the ele...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/64G05B19/04
Inventor 唐飞王晓浩再帕尔.阿不力孜陈一贺玖明
Owner TSINGHUA UNIV