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SepHaniadelavayi Diels total alkaloid extraction and purification technology

A technology of total alkaloids and terrestrial alkaloids, which can be used in drug combinations, plant raw materials, plant/algae/fungus/moss components, etc., can solve problems such as extraction methods of terrestrial alkaloids, and achieve high extraction rate and strong adsorption capacity. , the effect of easy elution

Active Publication Date: 2012-08-15
CHENGDU YUQUAN LVJIAN TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the existing extraction process, there is no extraction method for the total alkaloids in the soil

Method used

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  • SepHaniadelavayi Diels total alkaloid extraction and purification technology
  • SepHaniadelavayi Diels total alkaloid extraction and purification technology
  • SepHaniadelavayi Diels total alkaloid extraction and purification technology

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Embodiment 1

[0192] This embodiment is the best embodiment of the present invention.

[0193] The process of extracting and purifying total alkaloids of the ground includes three steps of extraction, separation and purification, wherein the extraction includes the following sub-steps:

[0194] a1. Weigh 100g of the crude medicinal material powder, and first use 50ml of 0.5% dilute hydrochloric acid solution to swell, and the swelling time is 2h;

[0195] a2, after the swelling is completed, put the medicinal materials into the percolation cylinder layer by layer, slowly add 400ml of 0.5% dilute hydrochloric acid solution and soak for 12h;

[0196] a3, start percolation after the impregnation, the percolation speed is 5ml / min, when percolation until the percolation liquid reacts with bismuth potassium iodide reagent without precipitation, stop percolation, and collect 1780ml of percolation liquid;

[0197] a4. Use concentrated ammonia water to adjust the pH value of the percolation liquid ...

Embodiment 2

[0204] The process of extracting and purifying total alkaloids of the ground includes three steps of extraction, separation and purification, wherein the extraction includes the following sub-steps:

[0205] a1. Weigh 100g of the crude medicinal material powder, and first use 50ml of 0.5% dilute sulfuric acid solution to swell, and the swelling time is 2h;

[0206] a2, after the swelling is completed, put the medicinal materials into the percolation cylinder layer by layer, slowly add 400ml of 0.5% dilute sulfuric acid solution and soak for 12h;

[0207] a3, start percolation after the impregnation, the percolation speed is 5ml / min, when percolation until the percolation liquid reacts with bismuth potassium iodide reagent without precipitation, stop percolation, and collect 1780ml of percolation liquid;

[0208] a4. Use concentrated ammonia water to adjust the pH value of the percolation liquid to 9-10 to produce a large amount of precipitates, filter them with suction, and dr...

Embodiment 3

[0215] The process of extracting and purifying total alkaloids of the ground includes three steps of extraction, separation and purification, wherein the extraction includes the following sub-steps:

[0216] a1. Weigh 100g of coarse medicinal material powder, and first use 100ml of 0.1% dilute hydrochloric acid solution to swell, and the swelling time is 3h;

[0217] a2, after the swelling is completed, put the medicinal materials into the percolation cylinder layer by layer, slowly add 500ml of 0.1% dilute hydrochloric acid solution and soak for 15h;

[0218] a3. Start percolation after the impregnation, and the percolation speed is 3ml / min. When the percolation solution reacts with bismuth potassium iodide reagent without precipitation, stop percolation, and collect 1780ml of percolation solution altogether;

[0219] a4. Use concentrated ammonia water to adjust the pH value of the percolation liquid to 9-10 to produce a large amount of precipitates, filter them with suction,...

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Abstract

The invention discloses a SepHaniadelavayi Diels total alkaloid extraction and purification technology comprising the steps of extraction: performing percolation on coarse powder of SepHaniadelavayi Diels medicinal materials, adjusting the pH value of percolation liquid through stronger ammonia water to obtain precipitate, and drying the precipitate in a vacuum drier to constant weight to obtain SepHaniadelavayi Diels total alkaloid; separation: making the SepHaniadelavayi Diels total alkaloid to SepHaniadelavayi Diels sample liquid, and adsorbing the SepHaniadelavayi Diels sample liquid by virtue of a processed adsorption column filled with macroporous adsorption resin; and purification: performing elution on the sample sequentially with distilled water and ethanol solution with the concentration being 75% after adsorption, collecting eluate, and drying the eluate by distillation to obtain dry paste. The technology has the beneficial effects that all alkaloid in SepHaniadelavayi Diels can be extracted once, and the extraction efficiency is high, thereby being beneficial to the comprehensive utilization of precious natural resources; the adsorptive capacity of the macroporous adsorption resin on the alkaloid is strong, the elution is easy and convenient, the elution rate is high, and the purity is high; and the process steps are less, the operation is simple, and thus the technology is convenient to be applied to practical production.

Description

technical field [0001] The invention relates to the technical field of alkaloid extraction, in particular to a process for extracting and purifying total alkaloids. Background technique [0002] Sephaniadelavayi Diels is the root tuber of SepHaniadelavayi Diels. Mainly distributed in Yunnan and Sichuan and other places. It has the functions of clearing heat and detoxifying, eliminating phlegm, cutting off malaria, and relieving pain. It mainly treats diseases such as carbuncle, sore throat, closed throat, malaria, and stomach pain. [0003] Alkaloids refer to a class of nitrogen-containing heterocyclic organic compounds in traditional Chinese medicine, which are alkaline and have significant physiological activity. At present, there are five to six thousand kinds of alkaloids isolated from plants, and some alkaloids have become research hotspots in recent years because of their anti-cancer, anti-tumor, low toxicity and low cost. Scientifically and efficiently extracting a...

Claims

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Application Information

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IPC IPC(8): A61K36/59A61P29/00A61P35/00
Inventor 彭腾
Owner CHENGDU YUQUAN LVJIAN TECH
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