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Process for production of antimicrobial medical instrument, and antimicrobial medical instrument

A technology of medical equipment and manufacturing methods, applied in the fields of pharmaceutical formula, medical science, catheters, etc., can solve the problems of inability to maintain antibacterial properties for a long time, antibacterial agent falling off, etc., and achieve the effect of maintaining antibacterial properties for a long time

Active Publication Date: 2012-08-15
TERUMO KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Therefore, there is such a problem in use: when the central venous catheter is inserted into the body, the antibacterial agent layer on the surface of the central venous catheter rubs, and the antibacterial agent is likely to fall off the surface of the central venous catheter, and the antibacterial property cannot be maintained for a long time

Method used

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  • Process for production of antimicrobial medical instrument, and antimicrobial medical instrument
  • Process for production of antimicrobial medical instrument, and antimicrobial medical instrument
  • Process for production of antimicrobial medical instrument, and antimicrobial medical instrument

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] In Example 1, the antibacterial tube A was produced according to the production method described in the above-described embodiment, and a peeling test was performed to determine whether or not the antibacterial agent adhering to the surface of the antibacterial tube A was easily detached. Moreover, since the 2nd solvent which melt|dissolved a medical instrument was used, it also confirmed whether the shape of the antibacterial tube A was deformed or not.

[0089] In addition, as a comparative example, a solvent different from the mixed solvent of the present invention was prepared, and comparative examples 1 and 2 produced from the mixed solvent were prepared simultaneously, and a test for deformation of the medical device and a peeling test for the antibacterial agent were performed together.

[0090] (Example 1)

[0091] Example 1 uses a polyurethane tube as a medical device. This urethane tube was made of urethane (manufactured by Nippon Milactron, trade name "E990"...

Embodiment 2、 comparative example 4

[0128] Example 2 Antibacterial tube E was produced in the same manner as in Example 1. In addition, the antibacterial tube F was manufactured similarly to the comparative example 2 in the comparative example 4.

[0129] About the manufactured antibacterial tube E and antibacterial tube F, surface photograph (photographing direction: oblique to the tube surface, magnification: 3000 times) and a cross-sectional photograph (magnification: 3000 times), and the state of the antibacterial agent dissolved on the surface was visually confirmed. Furthermore, surface photos ( Figure 8 , Figure 10 ), cross-section photos ( Figure 9 , Figure 11 ), the antibacterial agent was photographed as granular.

[0130] It can be confirmed that the antibacterial tube E of Example 2 is as Figure 8 , Figure 9 As shown, a part of the antibacterial agent was dissolved on the surface of the antibacterial tube E in an exposed state. From this, it turned out that the antibacterial tube E did ...

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Abstract

A process for producing an antimicrobial medical instrument, characterized by comprising: an adhesion step of adhering an solvent containing an antimicrobial agent, which is produced by dispersing particles of the antimicrobial agent in a mixed solution comprising a first solvent and a second solvent having different boiling points from each other, onto the surface of at least a part of a medical instrument which is to be inserted into the body; and a drying step of drying the antimicrobial-agent-containing solvent adhered onto the surface of the medical instrument.

Description

technical field [0001] The present invention relates to a method for producing an antibacterial medical device and an antibacterial medical device produced according to the production method, and in particular, is characterized in that an antibacterial agent is fixed on the surface of the medical device. Background technique [0002] A central venous catheter is exemplified as one of the antibacterial medical instruments imparted with antibacterial properties. The central venous catheter is a device for inserting the skin piercing part of the central venous catheter into the subclavian vein or the jugular vein, and indwelling the tip of the central venous catheter in the superior vena cava for a long time. [0003] In addition, the central venous catheter is provided with antibacterial properties in order to avoid the risk of bacteria entering the body through the skin piercing part or the lumen of the central venous catheter and causing bacterial infection. In addition, si...

Claims

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Application Information

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IPC IPC(8): A61L31/00A61L29/00A61M25/00
CPCA61M25/0045A61L29/06A61L29/106A61L2300/102A61L2300/404A61L2300/622A61M2025/0056C08L75/04
Inventor 竹村直人
Owner TERUMO KK
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