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Process for production of antimicrobial medical instrument, and antimicrobial medical instrument

A technology of medical equipment and manufacturing methods, applied in the fields of pharmaceutical formula, medical science, catheters, etc., can solve the problems of inability to maintain antibacterial properties for a long time, antibacterial agent falling off, etc., and achieve the effect of maintaining antibacterial properties for a long time

Active Publication Date: 2015-03-25
TERUMO KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Therefore, there is such a problem in use: when the central venous catheter is inserted into the body, the antibacterial agent layer on the surface of the central venous catheter rubs, and the antibacterial agent is likely to fall off the surface of the central venous catheter, and the antibacterial property cannot be maintained for a long time

Method used

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  • Process for production of antimicrobial medical instrument, and antimicrobial medical instrument
  • Process for production of antimicrobial medical instrument, and antimicrobial medical instrument
  • Process for production of antimicrobial medical instrument, and antimicrobial medical instrument

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] In Example 1, the antibacterial tube A was manufactured according to the production method described in the above-mentioned embodiment, and a peeling test was performed to see whether the antibacterial agent dissolved on the surface of the antibacterial tube A was easy to fall off. In addition, since the second solvent for dissolving the medical device is used, it is also checked whether the shape of the antibacterial tube A is deformed or not.

[0089] In addition, as a comparative example, a solvent different from the mixed solvent of the present invention was prepared, and Comparative Examples 1 and 2 produced from the mixed solvent were prepared, and a test of whether the medical device was deformed and an antibacterial agent peeling test were performed together.

[0090] (Example 1)

[0091] Example 1 uses a polyurethane tube as a medical device. The polyurethane tube was formed from polyurethane (manufactured by Nippon Milactran Co., Ltd., trade name "E990") to h...

Embodiment 2、 comparative example 4

[0128] Example 2 An antibacterial tube E was produced in the same manner as in Example 1. In addition, in Comparative Example 4, the antibacterial tube F was produced in the same manner as in Comparative Example 2.

[0129] For the produced antibacterial tube E and antibacterial tube F, a surface photograph (direction of photography: oblique to the surface of the tube, magnification: 3000 times), cross-sectional photos (magnification: 3000 times), visually confirm the state of the antibacterial agent dissolved on the surface. Furthermore, surface photos ( Figure 8 , Figure 10 ), cross-sectional photos ( Figure 9 , Figure 11 ), the antimicrobial agent is photographed as granular.

[0130] It can be confirmed that the antibacterial tube E of embodiment 2 is as Figure 8 , Figure 9 As shown, a part of the antibacterial agent is dissolved on the surface of the antibacterial tube E in an exposed state. From this, it was found that the antibacterial tube E did not easil...

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Abstract

A process for producing an antimicrobial medical instrument, characterized by comprising: an adhesion step of adhering an solvent containing an antimicrobial agent, which is produced by dispersing particles of the antimicrobial agent in a mixed solution comprising a first solvent and a second solvent having different boiling points from each other, onto the surface of at least a part of a medical instrument which is to be inserted into the body; and a drying step of drying the antimicrobial-agent-containing solvent adhered onto the surface of the medical instrument.

Description

technical field [0001] The present invention relates to a method of manufacturing an antibacterial medical device and an antibacterial medical device manufactured according to the manufacturing method. In particular, the present invention is characterized in that an antibacterial agent is immobilized on the surface of the medical device. Background technique [0002] One of the antibacterial medical devices endowed with antibacterial properties includes central venous catheters. This central venous catheter is a device that inserts the skin-punctured part of the central venous catheter into the subclavian vein or the jugular vein, and indwells the tip of the central venous catheter in the superior vena cava for a long period of time. [0003] In addition, the central venous catheter is endowed with antibacterial properties in order to avoid the risk of bacteria entering the body through the skin penetration part or lumen of the central venous catheter and causing bacterial i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/00A61L29/00A61M25/00
CPCA61L2300/404A61M25/0045A61L29/106A61L2300/102A61L29/06A61M2025/0056A61L2300/622
Inventor 竹村直人
Owner TERUMO KK
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