Medicine balloon based on hydrogen bond effects and coating method thereof

A technology of hydrogen bonding and drug layer, which is applied in coatings, drug delivery, and pharmaceutical formulations, can solve the problems of vascular endothelial cell proliferation, vascular restenosis, tearing, etc., and achieve the effect of increasing hydrophilicity

Inactive Publication Date: 2012-09-12
SHANGHAI MICROPORT ENDOVASCULAR MEDTECH (GRP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the analysis of clinical results for many years shows that this technique still has some complications, such as inflammation, vascular intima tear, vascular endothelial cell proliferation, etc., which may lead to vascular restenosis

Method used

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  • Medicine balloon based on hydrogen bond effects and coating method thereof
  • Medicine balloon based on hydrogen bond effects and coating method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 75 mg of paclitaxel and 30 mg of trihexyl citrate were dissolved in 4 ml of acetone and aqueous solution (acetone: water = 7.5: 1), and ultrasonicated for 10 min to form a uniformly dispersed mixed solution.

[0041] The above solution was sprayed on 5 untreated nylon-based balloons (3.0*20) respectively, so that the drug loading amount reached 3 μg / mm 2 left and right, drying, and folding to obtain the medicine balloon a.

[0042] The above solution was sprayed on the surface of 5 nylon-based balloons (3.0*20) that had been treated with plasma oxygen for 5 minutes, so that the drug loading amount reached 3 μg / mm 2 left and right, drying, and folding to obtain the drug balloon b.

[0043] Observing the balloon with an electron microscope, it was found that during the folding process of the balloon, there was a little drug shedding phenomenon in the drug balloon a, and when the folded balloon a was inflated again, the drug shedding phenomenon also appeared at the folded...

Embodiment 2

[0045] The nylon-based balloon was subjected to ozonation treatment for 10 min, so that the surface of the balloon had -O-O groups; 75 mg of paclitaxel and 45 mg of PEG (Mw<5000) were dissolved in 4 ml of acetone and ethanol (acetone: ethanol = 3: 1 ) to form a mixed solution, spray the above solution on the surface of the balloon, dry, and fold to obtain the drug balloon.

Embodiment 3

[0047] The nylon-based balloon was subjected to X-ray treatment for 3 minutes; 75 mg of rapamycin and 45 mg of PEG (Mw<5000) were dissolved in 4 ml of acetone and ethanol (acetone: ethanol = 3: 1) to form a mixed solution, and the above The solution is sprayed on the surface of the balloon, dried and folded to obtain the drug balloon.

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PUM

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Abstract

The invention relates to the medical instrument field, and concretely relates to a medicine balloon based on a hydrogen bond effect. The medicine balloon comprises a balloon surface and a medicine coating containing active medicines, wherein the balloon surface is processed or modified to have hydrophilic groups, and the hydrogen bond effects exist between the balloon surface and the medicine coating. The invention also relates to a coating method of the medicine balloon. The hydrogen bond effects which increase the adhesion force between the medicine coating and the balloon surface guarantee the ductility of the coating, and are benefit for loading the medicines on the balloon surface.

Description

technical field [0001] The invention relates to the field of medical instruments. More specifically, the present invention relates to a drug balloon based on hydrogen bonding and its coating method. Background technique [0002] Since the 1970s, intraluminal balloon angioplasty has been widely used in the treatment of vascular stenosis caused by atherosclerosis. Although the immediate therapeutic effect of balloon angioplasty is satisfactory, the high incidence of surgical complications, especially restenosis, limits its clinical application. [0003] Intravascular stenting is to implant a stent (bare stent or drug stent) in the stenosis area while the balloon is inflated. The stent can resist restenosis caused by vascular delamination and elastic recoil, and can significantly reduce the acute complications of interventional treatment. or subacute ischemic complications. However, analysis of clinical results over the years has shown that this technique still has some comp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/16A61L31/08A61L31/14C08J7/12C08J7/043C08J7/046
CPCA61L31/08A61L31/16A61L2400/18C08J2321/02C08J7/043C08J7/046
Inventor 郭芳谢志永卢惠娜李孝秀张滢涛孙芳华常孟琪宋林飞罗七一
Owner SHANGHAI MICROPORT ENDOVASCULAR MEDTECH (GRP) CO LTD
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