Micro-flow controlled air operated valve chip

Abstract

The invention discloses a micro-flow controlled air operated valve chip. The chip comprises a cover, a double-sided adhesive tape a, elastic film, a double-sided adhesive tape b and a base board sequentially superimposed from top to bottom; the double-sided adhesive tape a is etched with a fluid channel, and the cover and the elastic film are respectively two opposite side walls of the fluid channel; a sample inlet and a sample outlet of the fluid channel are communicated with the outside; at least one control channel is etched on the double-sided adhesive tape b, and the elastic film and the base board are respectively two opposite side walls of the control channel; one end of the control channel is a closed end, the other end of the control channel is an opening end, and the opening end is communicated with the outside; and the fluid channel and the control channel are vertically arranged in a cross way in a plane. According to the micro-flow controlled air operated valve chip, double-sided adhesive tapes and commercialized macromolecular elastic film are adopted as raw materials, the cost on materials is low, and the materials are easy to obtain; and the chip is easy and rapid to manufacture by the linkage of the chip via the pasting of adhesive agent on the double-sided adhesive tapes, and the scope of selection of the chip materials can be greatly broadened.

Description

technical field [0001] The invention relates to a microfluidic pneumatic valve chip, belonging to the technical field of microfluidic chips. Background technique [0002] Microfluidic chip is based on micro-electromechanical processing technology, which forms a network of micro-channels on the chip, and uses controllable micro-fluids to run through the entire system and complete various biological and chemical processes. Due to the advantages of low consumption, easy integration, high throughput and fast analysis speed, microfluidic chips have been widely used in chemistry, biology, medicine and other fields, and have begun to gradually develop from the laboratory research stage to commercial application. [0003] Microfluidic manipulation technology is the core content of microfluidic chips. Almost all biological and chemical reactions and detection processes realized on microfluidic chips are realized by fluid manipulation. Microvalve is one of the most important function...

AI Technical Summary

Problems solved by technology

Although this kind of chip has the above-mentioned advantages, because the PDMS material is easy to cause gas leakage or pollution due to the porous body, and has poor resistance to organic solvents; in addition, the preparation process of PDMS chips requires steps such as photolithography and plasma activation-assisted bonding, and the production cycle is long. The process is cumbersome, the equipment is expensive, and requires an ultra-clean processing environment, so it is limited to the application of some scientific research laboratories and is difficult to popularize

In recent years, many non-PDMS materials have been used in the processing of pneumatic valve microfluidic chips. For example, Mathies proposed a glass / PDMS / glass hybrid chip (W.H.Grover, A.M.Skelley, C.N.Liu, E.T.Lagally, R.A.Mathies, Sensors and Actuators B,2003,89,315-323.), but the glass channel processing of the chip still needs to use the photolithography process, so the above shortcomings are not overcome; Mathies and Yang proposed a PMMA / PDMS / PMMA hybrid chip (W.H.Zhang, S.C.Lin, C.M.Wang, J.Hu, C.Li, Z.X.Zhuang, Y.L.Zhou, R.A.Mathies, C.Y.J.Yang, Lab on a Chip, 2009, 9, 3088-3094.) preparation method, the fluid channel and the control The channel is processed on two PMMA substrates by laser etching, and the PDMS diaphragm is still used as the working device in the middle. Although this chip processing method avoids expensive and cumbersome photolithography process, it requires complex post-processing procedures to obtain a smooth bottom. In addition, before the bonding between PDMS and PMMA, the surface activation treatment process of ultraviolet light irradiation with a specific wavelength is still required; recently, Manalis proposed to use commercial Teflon film and glass substrate thermocompression bonding method to prepare pneumatic Valve chip (W.H.Grover, M.G.von Muhlen, S.R.Manalis, Lab on a Chip, 2008, 8, 913-918.), similarly, Ogilvie proposed to use the commercial Viton film and COC and PMMA surfaces to be activated by oxygen plasma respectively Microfluidic pneumatic valve chip prepared by thermocompression bonding after silanization treatment (I.R.G.Ogilvie, V.J.Sieben, B.Cortese, M.C.Mowlem, H.Morgan, Lab on a chip, 2011, 11, 2455-2459. ), although these two methods avoid using PDMS as the diaphragm material of the pneumatic valve chip, the channel processing and bonding process of the chip are more complicated

In summary, the existing microfluidic pneumatic valve chips either have poor diaphragm material properties, or have high chip processing costs, cumbersome processes, and long production cycles.

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