Chinese medicine composition for treating wind-heat type common cold and preparation method of Chinese medicine composition
A wind-heat cold and composition technology, applied in the field of traditional Chinese medicine compositions for treating wind-heat cold, can solve the problems of lack of research, little technical inspiration, unstable drug efficacy and the like, saving time, reducing production costs, and monitoring product quality. handy effect
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Embodiment 1
[0037] Example 1: Preparation of Xinqin Kegan Granules
[0038] 1. Prescription:
[0039]
[0040] 2, the preparation of Chinese medicine composition:
[0041] 1) Crush Houttuynia cordata into small pieces of 2-3cm according to the above prescription amount, and crush Scutellaria baicalensis, Bupleurum and Pueraria root into the coarsest powder (that is, all of them can pass through the No. 1 sieve, but the mixture can pass through the No. 20% powder), spare;
[0042] 2) Mix the crushed medicinal materials, add 8 times the weight of 70% (V / V) ethanol, heat and reflux at 75°C for 2 hours, filter, and use 8 times the weight of 70% (V / V) ethanol at 75°C Heat and reflux for extraction for 2 hours, filter, and combine the filtrates extracted twice to obtain an alcohol extract;
[0043] 3) Concentrate the alcohol extract under reduced pressure to a fluid extract with a relative density of 1.05-1.10 (measured at 60°C), then add water to make 0.5g of crude drug per ml (that is, ...
Embodiment 2
[0049] Embodiment two: the pharmacodynamic experiment of Chinese medicine composition
[0050] [Test drug] name of the test drug: the traditional Chinese medicine composition obtained in the manner described in Example 1 (hereinafter referred to as "traditional Chinese medicine composition" for short unless otherwise indicated), wherein each gram of Chinese medicine composition is equivalent to 16.47g of crude drug;
[0051] Positive control drugs: Aspirin enteric-coated tablets, 25mg / tablet, Shaanxi Bailu Pharmaceutical Co., Ltd., batch number: 101127; prednisone acetate tablets, 5mg / tablet, Zhejiang Xianju Pharmaceutical Co., Ltd., batch number: 101279.
[0052] [Animals] ICR strain mice (SPF), body weight 18-22g, license number: SCXK (Shaanxi) 2007-001; SD strain rats (SPF), body weight 180-210g, license number: SCXK (Shaanxi) 2007 -001; all were provided by the Experimental Animal Center of Xi'an Jiaotong University School of Medicine. New Zealand big-eared white rabbits,...
Embodiment 3
[0261] Embodiment three: animal acute toxicity experiment of Chinese medicine composition
[0262] 【experiment material】
[0263] 1. Experimental drug Name of the experimental drug: traditional Chinese medicine composition extract powder; Provider: Xi'an Xintong Pharmaceutical Research Co., Ltd.; each gram of extract powder is equivalent to 16.47g of crude drug, batch number: 20100914; the required concentration is prepared with distilled water.
[0264] 2. Experimental animals ICR strain mice, half male and half male, weighing 18-22 g, license number "SCXK (Shaanxi) 2007-001", provided by the Experimental Animal Center of Xi'an Jiaotong University School of Medicine. Animals were housed in separate cages, fed solid feed, and had free access to water. The feed was provided by the Experimental Animal Center of Xi'an Jiaotong University School of Medicine. The room temperature is 18-20°C, and the relative humidity is 60%-70%.
[0265] 【Test method and result】
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