Thermo-sensitive polymeric hydrogel and preparation method thereof

A polymer hydrogel and temperature-sensitive technology, which is applied in the field of temperature-sensitive polymer hydrogel and its preparation, and achieves the effects of good application prospect, good temperature sensitivity and simple preparation process

Inactive Publication Date: 2012-09-26
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Related domestic patents include the patent application number 200610148155, which is a temperature-sensitive amphiphilic block copolymer composed of polyethylene glycol as a hydrophilic block and degradable polyester as a hydrophobic block. Form a hydrogel in the water phase at body temperature (or normal temperature), and then obtain a stable, temperature-sensitive, and degradable chemically cross-linked hydrogel by using macromer technology; patent 200710156143.1 uses the sh

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take 10kg of acrylic acid, 44.17kg of lauryl alcohol polyoxyethylene ether (polymerization degree is 3), 0.016kg of inhibitor hydroquinone, 0.813kg of catalyst p-toluenesulfonic acid, heat reaction at 110°C for 6 hours; after the reaction is completed, Acrylic acid-lauryl polyoxyethylene ether copolymer is obtained; 6kg of copolymer, acrylic acid 1.161kg, butyl acrylate 2.065kg, initiator benzoyl peroxide 0.046kg, crosslinking agent ethylene glycol dimethacrylate 0.092kg , polymerized at 80°C for 7 hours to obtain a thermosensitive hydrogel with a phase transition temperature of 15°C. At around 15°C, the volume of the gel shrinks by about 25%.

Embodiment 2

[0025] Take 10kg of acrylic acid, 50.28kg of lauryl alcohol polyoxyethylene ether (polymerization degree is 4), 0.016kg of inhibitor hydroquinone, 0.904kg of catalyst p-toluenesulfonic acid, heat and react at 105°C for 5.5 hours; after the reaction is completed, Obtain acrylic acid-lauryl polyoxyethylene ether copolymer; By copolymer 6kg, acrylic acid 1.038kg, butyl acrylate 1.846kg, initiator benzoyl peroxide 0.044kg, crosslinking agent ethylene glycol dimethacrylate 0.178kg , polymerized at 90°C for 6 hours to obtain a thermosensitive hydrogel with a phase transition temperature of 22°C. At around 22°C, the volume of the gel shrinks by about 30%.

Embodiment 3

[0027] Take 10kg of acrylic acid, 68.61kg of lauryl alcohol polyoxyethylene ether (the degree of polymerization is 7), 0.016kg of inhibitor hydroquinone, and 1.179kg of catalyst p-toluenesulfonic acid, and heat the reaction at 107°C for 5 hours; after the reaction is completed, Obtain acrylic acid-lauryl polyoxyethylene ether copolymer; Copolymer 6kg, acrylic acid 0.788kg, butyl acrylate 1.401kg, initiator benzoyl peroxide 0.041kg, crosslinking agent ethylene glycol dimethacrylate 0.246kg , polymerized at 85°C for 6.5 hours to obtain a thermosensitive hydrogel with a phase transition temperature of 68°C. At around 68°C, the volume of the gel shrinks by about 45%.

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Abstract

The invention relates to thermo-sensitive polymeric hydrogel and a preparation method thereof. The raw materials of the thermo-sensitive polymeric hydrogel include the ester of acrylic acid/laurinol polyoxyethylene ether, acrylic acid, butyl acrylate and cross-linking agent in a weight ratio of (5-10):(1-2):(1-3):(0.08-0.8). The preparation method comprises the following steps of: (1) performing polymerization reaction of the acrylic acid, the laurinol polyoxyethylene ether, a polymerization inhibitor and a catalyst at 105-110 DEG C for 5-6 hours to obtain the ester of acrylic acid/laurinol polyoxyethylene ether; and (2) mixing the ester of acrylic acid/laurinol polyoxyethylene ether, acrylic acid, butyl acrylate and cross-linking agent, adding an initiator, and performing polymerization reaction at 80-100 DEG C for 5-7 hours to obtain the product. In the invention, the adopted new monomer has little toxicity and is colorless, tasteless and non-irritant; the prepared hydrogel is insoluble in water and has good thermo-sensitivity; and the preparation technology is simple and has low cost and good application prospects.

Description

technical field [0001] The invention belongs to the field of stimulus-responsive hydrogel and its preparation, and in particular relates to a temperature-sensitive polymer hydrogel and its preparation method. Background technique [0002] Stimuli-responsive hydrogels are a type of hydrogels whose properties will change significantly in response to slight physical or chemical stimuli from the external environment. It is a water-insoluble, water-swellable, hydrophilic cross-linked polymer. Stimuli-responsive hydrogels can respond to changes in external environmental factors such as temperature, pH, light, electric and magnetic fields. [0003] Thermosensitive hydrogel refers to a type of hydrogel whose volume changes with temperature changes. This type of hydrogel has a minimum critical solution temperature, and a sudden shrinkage or swelling of the volume will occur near this temperature. N-isopropylacrylamide is the main monomer for the preparation of thermosensitive hydro...

Claims

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Application Information

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IPC IPC(8): C08F290/06C08F220/28C08F220/06C08F220/18
Inventor 聂文洁刘洪玲邓云红于伟东章悦庭
Owner DONGHUA UNIV
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