Trimetaphan camsilate and linseed oil nanoemulsion antihypertensive drug

Abstract

The invention discloses an oil-in-water type trimetaphan camsilate and linseed oil nanoemulsion antihypertensive drug which comprises the following raw materials in percentage by weight: 1%-15% of trimetaphan camsilate, 15%-35% of surfactant, 0-20% of cosurfactant, 1%-25% of linseed oil and the balance of distilled water, wherein the sum of the mass percent of the raw materials is 100%. The nanoemulsion has the advantages of small emulsion drop granule, uniform distribution, small viscosity and good flowability. In the nanoemulsion dosage form, the hydralazine which is a water-soluble medicine and the fat soluble linseed oil are organically combined, so the dissolving and infiltration capacities of the linseed oil are improved, and the stability and the pesticide effect of the trimetaphan camsilate are improved; and after the trimetaphan camsilate and the linseed oil are prepared into the nano dosage form, the advantages of the trimetaphan camsilate and the linseed oil are combined, so the antihypertensive effect is obviously increased, the half-life period of the drug is prolonged, and the drug administration times is reduced.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new dosage form of antihypertensive drug camphoramiphene and linseed oil, in particular to a kind of antihypertensive drug camphoramiphene and linseed oil nanoemulsion. [0002] Background technique [0003] Trimetaphan camsilate is also known as trimetaphan camphorsulfonate, mithiaphene. White crystalline powder with a melting point of about 245°C. This drug is a controlled antihypertensive drug, which can inhibit the conduction of sympathetic ganglion nerve impulses, dilate peripheral blood vessels, and lower blood pressure. It is mainly used for controlled hypotension and reduces vascular tension. [0004] This product competes with acetylcholine for the nicotinic (N1) receptor on the ganglion cell membrane, thereby blocking the nerve impulse transmission of the sympathetic and parasympathetic ganglion, causing peripheral blood vessel expansion, blood pressure drop and other effects...

AI Technical Summary

Problems solved by technology

[0008] Existing antihypertensive drugs such as camphorsulfaphene tablets on the market now also have the use of linseed oil, although they can be absorbed from the gastrointestinal tract after oral administration, the absorption is not complete, and the dissolution rate of the medicine is slow in addition, and the bioavailability is poor. Coupled with the slow action of tamophen, the efficacy of tamophen and linseed oil cannot be fully utilized