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Probiotic bifidobacterial composition in accordance with secretor blood group status

A technology for bifidobacteria, microbial compositions, applied in growth and/or functional applications, capable of solving problems of high ecosystem complexity

Inactive Publication Date: 2012-11-07
DUPONT NUTRITION BIOSCIENCES APS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ecosystem complexity is simply too high

Method used

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  • Probiotic bifidobacterial composition in accordance with secretor blood group status
  • Probiotic bifidobacterial composition in accordance with secretor blood group status
  • Probiotic bifidobacterial composition in accordance with secretor blood group status

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Experimental program
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Embodiment 1

[0072] Secretor status was determined from blood samples using standard in-house blood typing procedures of the Finnish Red Cross Blood Service. The secretor status of 59 individuals was determined, of which 48 were secretors and 7 were non-secretors. Secretor status could not be determined for 4 samples.

Embodiment 2

[0074] DGGE analysis for fecal Bifidobacterium populations was performed as described in Materials and Methods above. DGGE gel images showed that the number of bands in samples obtained from non-secretor individuals was lower than in samples from secretor individuals, suggesting that there were more Bifidobacteria genotypes present in non-secretor individuals than in secretor individuals. few. On average, non-secretors had 2.5 (up to 4) bands and secretors 5.2 bands (up to 11 bands) in the DGGE profile of bifidobacteria. Bifidobacteria were not detected in five samples (1 non-secretor sample, 4 secretor samples). Bifidobacteria information for all non-secretor individuals and selected Bifidobacteria information for secretor individuals are shown in figure 1 middle.

Embodiment 3

[0076] DGGE analysis of fecal Bifidobacteria populations was performed as described above. Principal component analysis (PCA) was performed using the tools provided in the Bionumerics software package. PCA based on the intensity of the bands detected by DGGE was used to establish coordinates for the samples and find the bands that contribute most to the principal components. DGGE gel images were analyzed using Bionumerics to perform statistical analysis across samples. PCA based on the intensity of the bands in the DGGE gel showed that samples obtained from non-secretors clustered into one group. The first and second principal components explained 56.3% of the total variance. The results are shown in figure 2 middle.

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Abstract

The present invention relates to a microbial or probiotic composition which is tailored based on the spectrum of bifidobacteria found in the intestine of at least one individual with secretor blood group phenotype but not commonly found in individuals of non-secretor blood group phenotype. The present invention further relates to a method of tailoring a microbial or probiotic composition based on the bifidobacteria found in the intestine of at least one individual with secretor blood group phenotype but not commonly found in individuals non-secretor blood group phenotype.

Description

technical field [0001] The present invention relates to a microbial or probiotic composition tailored according to the bifidobacterial profile present in the gut of at least one individual with a secretor phenotype but not commonly found in individuals with a non-secretor blood phenotype. The present invention also relates to a method of tailoring a microbial or probiotic composition based on the presence of Bifidobacteria in the gut of at least one individual with a secretor phenotype but not commonly found in individuals with a non-secretor phenotype. Furthermore, the present invention relates to the use of prebiotics, molecular compounds or additional supportive bacterial strains for expanding the growth and / or functionality of bifidobacteria in the intestine. The present invention also relates to the use of an individual's secretor status as a criterion for supplementation with Bifidobacterium-enriched probiotics. The present invention also relates to a method of assessin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/05A61K35/74
CPCA61K35/74A23L1/3014A23L33/135A61P1/00
Inventor P·瓦克林J·马托H·马基沃考
Owner DUPONT NUTRITION BIOSCIENCES APS