Unlock instant, AI-driven research and patent intelligence for your innovation.

Probiotic bifidobacterial composition in accordance with secretor blood group status ?

A bifidobacterium, bifidum bifidum technology, applied in the field of probiotic composition, can solve the problem of high complexity of the ecosystem

Inactive Publication Date: 2012-11-14
DUPONT NUTRITION BIOSCIENCES APS
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ecosystem complexity is simply too high

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Probiotic bifidobacterial composition in accordance with secretor blood group status ?
  • Probiotic bifidobacterial composition in accordance with secretor blood group status ?
  • Probiotic bifidobacterial composition in accordance with secretor blood group status ?

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Secretor status was determined from blood samples using standard in-house blood typing procedures of the Finnish Red Cross Blood Service. The secretor status of 59 individuals was determined, of which 48 were secretors and 7 were non-secretors. Secretor status could not be determined for 4 samples.

Embodiment 2

[0076] DGGE analysis for fecal Bifidobacterium populations was performed as described in Materials and Methods above. DGGE gel images showed that the number of bands in samples obtained from non-secretor individuals was lower than in samples from secretor individuals, suggesting that there were more Bifidobacteria genotypes present in non-secretor individuals than in secretor individuals. few. On average, non-secretors had 2.5 (up to 4) bands and secretors 5.2 bands (up to 11 bands) in the DGGE profile of bifidobacteria. Bifidobacteria were not detected in five samples (1 non-secretor sample, 4 secretor samples). Bifidobacteria information for all non-secretor individuals and selected Bifidobacteria information for secretor individuals are shown in figure 1 middle.

Embodiment 3

[0078] DGGE analysis of fecal Bifidobacteria populations was performed as described above. Principal component analysis (PCA) was performed using the tools provided in the Bionumerics software package. PCA based on the intensity of the bands detected by DGGE was used to establish coordinates for the samples and find the bands that contribute most to the principal components. DGGE gel images were analyzed using Bionumerics to perform statistical analysis across samples. PCA based on the intensity of the bands in the DGGE gel showed that samples obtained from non-secretors clustered into one group. The first and second principal components explained 56.3% of the total variance. The results are shown in figure 2 middle.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to a probiotic composition which is tailored based on the spectrum of bifidobacteria found in the intestine of at least one individual with non-secretor blood group phenotype. The present invention further relates to a method of tailoring a probiotic composition based on the bifidobacteria found from the intestine of at least one non-secretor individual.

Description

technical field [0001] The present invention relates to a probiotic composition tailored to the bifidobacterial profile found in the intestine of at least one individual with a non-secretor blood group phenotype. The present invention also relates to a method of tailoring a probiotic composition based on the bifidobacteria found in the intestine of at least one non-secretor individual. The present invention also relates to the use of an individual's secretor status as a criterion for supplementation with Bifidobacterium-enriched probiotics. The present invention also relates to a method of assessing the need for supplementation of Bifidobacterium-enriched probiotics in an individual by determining the secretion status of the individual. Furthermore, the present invention relates to the use of prebiotics, molecular compounds or additional supportive bacterial strains for increasing the number and / or expanding the growth and / or functionality of bifidobacteria in the intestine. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/05A61K35/745
CPCA61K31/7016A61K31/716A61K35/745A61P1/00A61K2300/00
Inventor P·瓦克林J·马托H·马基沃考
Owner DUPONT NUTRITION BIOSCIENCES APS