Unlock instant, AI-driven research and patent intelligence for your innovation.

Application of gastrin in anion exchangers 2

A technology for exchanging proteins and gastrin, applied in the fields of molecular biology, cell biology, and pharmacology, can solve the problems of atrophic gastritis, affecting digestive function, and affecting the quality of life of patients

Inactive Publication Date: 2013-01-02
SHANGHAI BOAODE MEDICAL TECH
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because omeprazole will affect the digestive function while inhibiting gastric acid, causing discomfort symptoms such as abdominal distension, and even atrophic gastritis, which affects the quality of life of patients, and chronic atrophic gastritis and gastric acid deficiency are related to the occurrence of gastric cancer

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of gastrin in anion exchangers 2
  • Application of gastrin in anion exchangers 2
  • Application of gastrin in anion exchangers 2

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Anion exchange protein 2 (AE2) exists in human kidney, intestine, blood vessels, lung, bile duct epithelial cells, small intestinal mucosal crypt cells, brush border of villus cells and early pregnancy villi, among which gastric AE2 is most abundantly expressed. Once the abnormal expression of AE2, it will lead to many pathological changes. AE2- / - mice, on the other hand, showed thinness, inability to erupt teeth and severe growth retardation, and most died at weaning. In addition, the mice also showed no gastric acidosis. It can be seen that AE2 is an indispensable and important component of the body.

[0008] Anion exchange protein 2 is an important factor mediating gastrin regulation of intracellular pH. AE2 regulates intracellular pH, intracellular Cl - and HCO 3 - The metabolism of AE2 is distributed in a variety of cells, but the highest content is in the parietal cells. Pathologically, immunohistochemistry found that AE2 expression was absent or decreased i...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to application of gastrin in anion exchangers 2 in the medical field. The gastrin is used as modifier to be used for expressing the anion exchangers 2 and for preparing medicine for treating achlorhydria. The gastrin is used as the modifier of the anion exchangers 2, so that the traditional wrong ideas that increased secretion of gastric acid leads to the damage and repeated repairing of gastric mucosa and induces the gastric cancer, so that a great amount of proton pump inhibitors such as omeprazole are used for inhibiting the secretion of the gastric acid are remedied. The gastrin is used for appropriately promoting the secretion of the gastric acid and repairing the gastric mucosa so as to produce a beneficial effect for protecting the gastric mucosa; and at present no medicine for stimulating the secretion of the gastric acid is produced in the world, so that the gastrin has a good clinic application prospect.

Description

technical field [0001] The present invention relates to the fields of molecular biology, cell biology and pharmacology, in particular to the application of gastrin as a regulator in anion exchange protein 2. Background technique [0002] Gastrin, also known as gastrin, is located in the G region of chromosome 17 and has a length of 4.1 kb. It is an important peptide gastrointestinal hormone, which is mainly secreted by G cells in the gastric pyloric mucosa. There are three types of gastrin peptides produced by the human body: the most active one is a polypeptide synthesized from 17 amino acids, called small gastrin, which is the main form of gastric antrum extract: [0003] 1. Gastrin-34 has 34 amino acids, called biggastrin; [0004] 2. Gastrin-17 has 17 amino acids, called littlegastrin; [0005] 3. Gastrin-14 has 14 amino acids, called minigastrin, and these 14 amino acids have all the physiological activities. The normal physiological value of human gastrin: fasting s...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/22A61K38/10A61P1/04
Inventor 索文昊王美乔
Owner SHANGHAI BOAODE MEDICAL TECH