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Effervescent tablet type low molecular weight collagen peptide and preparation method thereof

A technology of collagen peptide and low molecular weight, which is applied in the field of effervescent tablet low molecular weight collagen peptide and its preparation, can solve the problems of low yield and wide distribution range of collagen peptide, and achieve simple production process and high raw material utilization rate High, production cost reduction effect

Inactive Publication Date: 2013-01-23
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It not only solves the problem of high-molecular collagen contained in cosmetics that is difficult for the human body to absorb in the prior art, but also solves the problem of wide distribution and low yield of collagen peptides in industrial production; at the same time, it is the first to create collagen that does not contain preservatives New formulations of cosmetics

Method used

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  • Effervescent tablet type low molecular weight collagen peptide and preparation method thereof
  • Effervescent tablet type low molecular weight collagen peptide and preparation method thereof
  • Effervescent tablet type low molecular weight collagen peptide and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Remove non-collagenous proteins in pig skin:

[0037] Choose 500g of freshly chopped pig skin, wash and drain, under normal temperature conditions, soak it with a volume of 15L of 0.15mol / l NaOH solution at 25°C and stir at 200 rpm for 18 hours to remove non-collagenous proteins in pig skin. Then filter to get pig skin for use.

[0038] ⑵Remove fat from pig skin:

[0039] Put the pigskin treated in step (1) into 15L water, and use Na 2 CO 3 The powder was adjusted to a pH value of 9, and then 2.5g of lipase was added, and the mixture was stirred at a constant temperature of 35°C at 200 revolutions / min for 10 hours. Then filter and wash the pigskin with clean water for later use.

[0040] ⑶ Sol:

[0041] Put the cleaned pig skin in step (2) in 10 L of distilled water, at a constant temperature of 80°C, and stir at a low speed of 200 revolutions / min for 5 hours to obtain a mixture of pig skin and water-soluble collagen.

[0042] ⑷Preparation of trypsin digestion protein peptid...

Embodiment 2

[0051] (1) Remove non-collagenous proteins in pig skin:

[0052] Choose 500g of fresh pig skin, wash, drain, under normal temperature conditions, soak in a volume of 15L 0.1mol / l NaOH solution at room temperature 20℃, stir at low speed 100 revolutions / min for 20 hours to remove non-collagenous proteins in pig skin. Then filter to get pig skin for use.

[0053] ⑵Remove fat from pig skin:

[0054] Put the pigskin treated in step (1) into 15L water, and use Na 2 CO 3 Adjust the pH of the water to 9.3 by the powder, then add 5 g of lipase, and stir at a constant temperature of 35°C at a low speed of 100 rpm for 10 hours. Then filter and wash the pigskin with clean water for later use.

[0055] ⑶ Sol:

[0056] Put the cleaned pig skin in step (2) in 10 L of distilled water, at a constant temperature of 80°C, and stir at a low speed of 100 revolutions / min for 6 hours to obtain a mixture of pig skin and water-soluble collagen.

[0057] ⑷Preparation of trypsin digestion protein peptide solutio...

Embodiment 3

[0066] (1) Remove non-collagenous proteins in pig skin:

[0067] Choose 500g of fresh pig skin, wash and drain, under normal temperature conditions, soak with a volume of 15L 0.1mol / l NaOH solution at room temperature 20℃, stir at low speed 150 rpm for 24 hours to remove non-collagenous protein in pig skin. Then filter to get pig skin for use.

[0068] ⑵Remove fat from pig skin:

[0069] Put the pigskin treated in step (1) into 15L water, and use Na 2 CO 3 Adjust the pH of the powder to 9.2, and then add 5 g of lipase, and stir at a constant temperature of 35°C at a low speed of 150 revolutions / min for 10 hours. Then filter and wash the pigskin with clean water for later use.

[0070] ⑶ Sol:

[0071] Put the cleaned pig skin in step (2) in 10 L of distilled water, at a constant temperature of 80°C, and stir at a low speed of 150 revolutions / min for 6 hours to obtain a mixture of pig skin and water-soluble collagen.

[0072] ⑷Preparation of trypsin digestion protein peptide solution:

[...

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Abstract

The invention discloses effervescent tablet type low molecular weight collagen peptide and a preparation method of the effervescent tablet type low molecular weight collagen peptide. The preparation method comprises main steps of removing noncollagenous protein, degreasing by virtue of biological enzyme, soling, implementing enzymolysis by virtue trypsin, jointly discoloring by virtue of kieselguhr and macroporous resin, concentrating and drying, mixing with various beneficial raw materials, and pressing to obtain the effervescent tablets. With the adoption of the preparation method disclosed by the invention, the technical conditions for soling and enzymolysis are optimized based on conventional technology, so that the collagen peptide with molecular weight centrally distributed within the range from 500 to 1600Da is obtained, the follow-up technological operation is simplified, and the producing cost is reduced; the way of jointly discoloring the collagen peptide liquid by virtue of the kieselguhr and macroporous resin is first provided; and with the implementation of the way, good discoloring effect is obtained, and little collagen peptide is lost. In aspect of preparation, the effervescent tablets which are capable of beautifying and moisturizing and high in permeation of skin are adopted; and any preservatives are not added, so that the cosmetic is safe and beneficial for human skin.

Description

Technical field [0001] The invention relates to the field of collagen peptide extraction and application, and more specifically, to an effervescent tablet type low molecular weight collagen peptide and a preparation method thereof. Background technique [0002] Collagen or collagen is a kind of biopolymer compound synthesized by cells of animals (from sponges to vertebrates). It is widely present in animal bones, tendons, cartilage, skin and other connective tissues, and accounts for about 1% of total mammalian protein. / 3, more than 90% of the bones and tendons, and more than 50% of the protein in the skin is collagen. The hydrolysate of collagen, collagen peptide, has many functions such as anti-blood pressure, regulating immunity, anti-tumor, skin care and beauty. The collagen active peptide produced by proteolysis is mainly hydrolyzed by chemical and enzymatic methods. The chemical method uses acid or alkali to break the peptide bond of protein. Due to the extreme reaction e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P21/06C07K4/12C07K1/36C07K1/34C07K1/18A61K8/97A61K8/65A61K8/02A61Q19/00
Inventor 朱宏吉张华王世鹏滕欣余路明月姜珊方洁张鑫
Owner TIANJIN UNIV