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A kind of water-soluble carbon nanotube and its application

A carbon nanotube, water-soluble technology, used in carbon compounds, medical preparations containing active ingredients, inorganic chemistry, etc. And the effect of good chemical stability and rich source of raw materials

Inactive Publication Date: 2014-10-22
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In view of the above situation, in order to solve the defects of the prior art, the purpose of the present invention is to provide a water-soluble carbon nanotube and its application, which can effectively solve the problems that the existing tumor treatment drugs have large side effects and cannot well inhibit the proliferation of tumor cells

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 1) Weigh 119mg of carbon nanotubes, put them into a flask, add 120ml of mixed acid solution consisting of sulfuric acid with a mass concentration of 98% and nitric acid with a mass concentration of 65-68% in a volume ratio of 3:1, and then add 12ml of a mass concentration It is a 30% hydrogen peroxide solution, sonicated in a 300W ultrasonic cleaner for 1 hour, diluted with ultrapure water, filtered using a 0.45 μm microporous membrane and a Buchner funnel, and continuously rinsed with ultrapure water to pH =7, put it into an oven and dry at a constant temperature of 80°C to obtain carboxylated carbon nanotubes;

[0036] 2) Weigh 50mg of carboxylated carbon nanotubes, add 20ml of ethylenediamine, then add 1g of N,N'-dicyclohexylcarbodiimide, put it in a flask, ultrasonically disperse it for 10min, put it in an oil bath, Stir at 120°C and 100 r / min, condense and reflux for 48 hours, after the reaction, cool the reactant to room temperature, filter 10 times with a 0.22 μm...

Embodiment 2

[0039] 1) Weigh 110mg of carbon nanotubes, put them into a flask, add 120ml of mixed acid solution consisting of sulfuric acid with a mass concentration of 98% and nitric acid with a mass concentration of 65-68% in a volume ratio of 3:1, and then add 12ml of a mass concentration It is a 30% hydrogen peroxide solution, sonicated in an ultrasonic cleaner with a power of 350W for 1 hour, diluted with ultrapure water, filtered using a 0.45 μm microporous membrane and a Buchner funnel, and continuously rinsed with ultrapure water to pH =7, put it into an oven and dry at a constant temperature of 80°C to obtain carboxylated carbon nanotubes;

[0040] 2) Weigh 45mg of carboxylated carbon nanotubes, add 20ml of 1,6-hexanediamine, then add 1g of N,N'-dicyclohexylcarbodiimide, put it in a flask, ultrasonically disperse it for 10min, and put it in an oil bath In the pot, stir at 120°C and 100 r / min, condense and reflux for 48 hours, after the reaction, cool the reactant to room temperatu...

Embodiment 3

[0043] 1) Weigh 125mg of carbon nanotubes, put them into a flask, add 120ml of mixed acid solution consisting of sulfuric acid with a mass concentration of 98% and nitric acid with a mass concentration of 65-68% in a volume ratio of 3:1, and then add 12ml of a mass concentration It is a 30% hydrogen peroxide solution, sonicated in a 400W ultrasonic cleaner for 1 hour, diluted with ultrapure water, filtered using a 0.45 μm microporous membrane and a Buchner funnel, and continuously rinsed with ultrapure water to pH =7, put it into an oven and dry at a constant temperature of 80°C to obtain carboxylated carbon nanotubes;

[0044] 2) Weigh 50mg of carboxylated carbon nanotubes, add 20ml of 1,3-propanediamine, then add 1g of N,N'-dicyclohexylcarbodiimide, put it in a flask, ultrasonically disperse it for 10min, and put it in an oil bath In the pot, stir at 120°C and 100 r / min, condense and reflux for 48 hours, after the reaction, cool the reactant to room temperature, filter it wi...

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Abstract

The invention relates to water-soluble carbon nanotube and application thereof, which can effectively solve the problems of large side effect and incapability of excellently inhibiting tumor cell proliferation of the conventional tumor treatment medicament. The technical scheme for solving the problems is that the original carbon nanotube is firstly subjected to carboxylation based on purification treatment and then reacts with an ammoniation reagent; and after the surface of the carbon nanotube is bonded with an amino group with higher reaction activity, the carbon nanotube reacts with hyaluronic acid to form an amido bond to finally obtain carbon nanotube-hyaluronic acid polymer, i.e., water-soluble carbon nanotube, wherein the mass ratio of the carbon nanotube to the hyaluronic acid is 0.15-0.25:1. The water-soluble carbon nanotube has the advantages of good physical and chemical stability, capability of easily satisfying preparation conditions, rich raw material source, low cost and small side effect and is an innovation for a tumor treatment medicament carrier.

Description

technical field [0001] The invention relates to the field of chemical industry, in particular to a water-soluble carbon nanotube and its application. Background technique [0002] Since the discovery of multi-walled carbon nanotubes (MWNTs) and single-walled carbon nanotubes (SWNTs) in 1991 and 1993, respectively, carbon nanotubes (CNTs) have attracted attention from various disciplines due to their unique electrical, mechanical, optical and thermodynamic properties. extensive attention. Huge specific surface area (~2600m 2 / g), ultra-high mechanical strength, low density, outstanding chemical and thermal stability and electron-rich characteristics, unique transmembrane ability, and large delocalized π bonds, which can form a relatively good relationship with many biomedical molecules. The strong π-π bond interaction makes it have great application potential in the field of biomedicine. [0003] The lipophilicity of biomembranes limits the direct intracellular transport o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08C01B31/00A61K41/00A61K47/02A61K47/36A61P35/00C01B32/174
Inventor 史进进张红岭张振中高君叶凡刘艳余晓媛张静马柔柔刘瑞瑗王蕾侯琳
Owner ZHENGZHOU UNIV