Magnetic mesoporous bioactive glass drug delivery system and preparation method thereof

A bioglass and delivery system technology, applied in medical science, prosthesis, inorganic non-active ingredients, etc., can solve the problems of increased cytotoxicity and biocompatibility, and achieve increased drug loading, excellent drug loading and sustained release performance , the effect of simple equipment

Inactive Publication Date: 2013-02-13
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, their invention and preparation did not completely solve the related disease problems caused by bone repair transplantation, which m

Method used

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  • Magnetic mesoporous bioactive glass drug delivery system and preparation method thereof
  • Magnetic mesoporous bioactive glass drug delivery system and preparation method thereof
  • Magnetic mesoporous bioactive glass drug delivery system and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0024] Example 1-6

[0025] First place 4g of P123 in 50mL of ethanol and stir vigorously to obtain a homogeneous ethanol dispersion solution of surfactant; then prepare inorganic precursors to obtain SiO as shown in Table 1. 2 :CaO:P 2 O 5 :Fe 3 O 4 In the magnetic mesoporous bioglass drug delivery system with a mass ratio of, the inorganic substances are added in order, and the first group of embodiments are specifically: 1.25g calcium nitrate tetrahydrate, 8.6mL (8g) tetraethylorthosilicate (TEOS) , 0.35mL (0.37g) triethyl phosphate (TEP), 0.142g nano Fe 3 O 4 Particles, then add 1-3mL dilute HNO 3 (1mol / L) The solution is catalyzed and hydrolyzed at a reaction temperature of 40℃; after the inorganic precursor is hydrolyzed and dispersed uniformly, the surfactant ethanol dispersion solution is added, the reaction is fully mixed, and the soft template is sealed and self-assembled into a sol-gel. The product is 60 Drying in an oven at ℃ for 1-3 days, calcining the gel obtained af...

Example Embodiment

[0028] Example 7

[0029] According to the steps in Example 1, no magnetic nanoparticles were added, and other processes and conditions were the same as in Example 1. Finally, a mesoporous bioglass drug delivery system without magnetism was obtained, which was a blank control group.

Example Embodiment

[0030] Example 8

[0031] The magnetic mesoporous bioglass drug delivery system prepared in Example 1 was selected for drug loading and sustained release experiments.

[0032] (1) Drug load: weigh 30 mg of powdered gentamicin sulfate under the protection of inert gas in a glove box, and dissolve it in 50 mL of deionized water to prepare a 600 μg / mL gentamicin sulfate solution; take 0.5 g of sample and place it in the solution Stir vigorously for 24h at a constant temperature at 37°C. Centrifuge at 8000r / min, dry the lower sediment in a vacuum drying oven at 37°C, and leave the upper sediment for drug load testing.

[0033] (2) Drug release: Weigh 0.2g of the drug-loaded sample, press it into a sheet with a diameter of 2-3 cm with a tablet press, and soak the sample in 100 mL of deionized water. At different time points, use UV- The visible spectrophotometer detects the concentration of the drug in the solution. The drug release curve is as Figure 4 Shown.

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PUM

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Abstract

The invention discloses a magnetic mesoporous bioactive glass drug delivery system and a preparation method thereof, and the preparation process is carried out with a surface active agent as a soft template by a sol-gel method. The magnetic mesoporous bioactive glass drug delivery system is provided with a specific surface area of the material of 300-1000 cm<2>/g and a mesoporous diameter of 2-50 nm, and the structure of the mesoporous is adjustable. Through loading gentamicin sulphate and other antibiotics on the surface of the material and carrying out drug sustained release, the results shows that the magnetic mesoporous bioactive glass drug delivery system has good drug loading efficiency and slow release performance, and is not influenced by the types of the loaded antibiotics and the like.

Description

technical field [0001] The invention relates to the technical field of inorganic non-metallic materials and medical materials, in particular to the preparation of a magnetic mesoporous bioglass drug delivery system. Background technique [0002] Bioglass, as a kind of bone repair and scaffold material, has been successfully applied to a variety of tissue repair materials after clinical operations. The most important reason is that its chemical composition is very similar to human bone and has excellent biocompatibility And self-degradation performance, it can form a tight combination with bone after implanted in the human body, and quickly and effectively promote bone repair, so it has good osteogenesis performance. Nowadays, for bone defects caused by bone tumors and other diseases, biomaterials are not only required to effectively repair bone, but also have the function of treating related diseases. The development and expansion of new high-efficiency bioglass has become ...

Claims

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Application Information

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IPC IPC(8): A61K47/08A61K47/02A61L27/12A61L27/02A61L27/56
Inventor 郭亚平余锡宾刘怡卓阳俊
Owner SHANGHAI NORMAL UNIVERSITY
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