Cough-treating tendril-leaved fritillary bulb and loquat sustained release tablet and preparation method thereof

Abstract

The invention discloses a cough-treating tendril-leaved fritillary bulb and loquat sustained release tablet and a preparation method thereof. The preparation method comprises the following steps: (1) weighting raw materials; (2) adding water to loquat leaves, decocting, filtering, concentrating to obtain clear paste, adding ethanol, stirring sufficiently, standing and taking supernate for later use; (3) crushing tendril-leaved fritillary bulb, carrying out hot reflux extraction on the crushed tendril-leaved fritillary bulb together with platycodon root and perilla fruit by using ethanol, filtering, mixing the obtained filtrate with the supernate obtained in (2), recovering the ethanol, concentrating to obtain clear paste, cooling to room temperature, adding butanone for extraction, recovering the butanone, concentrating to obtain thick paste, and drying, crushing and sieving the thick paste to obtain extractive powder; and (4) adding a proper amount of binding agent into the extractive powder, a filling agent, hydroxypropyl methylcellulose and a release rate regulator to prepare a soft material, granulating, drying and tabletting. The sustained release tablet disclosed by the invention has the effects of relieving cough, eliminating phlegm and relieving asthma, and the sustained release tablet prepared from the raw materials extracted by using an extraction method disclosed by the invention is low in drug dose, high in content, convenient to take and carry, good in curative effect, favorable for fixed-quantity taking, and beneficial to storage and transportation.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine preparation, in particular to Chuanbei loquat sustained-release tablets for treating cough and a preparation method thereof. Background technique [0002] Cough Chuanbei Pipa Dew is prepared from traditional Chinese medicine raw materials: loquat leaves, platycodon grandiflorum, water pinellia, flat fritillaria liquid extract and menthol. It has antitussive and expectorant functions. For cough caused by cold and bronchitis. Its formula is: 68g of loquat leaves, 6g of platycodon grandiflorum, 20g of water pinellia, 7ml of flat fritillaria liquid extract, 0.15g of menthol. Once, filter, combine the filtrates, concentrate to an appropriate amount, add preservatives, filter, add 682g of sucrose, add flat fritillaria liquid extract and menthol in turn, add water to adjust to 1000ml, shake well, and get ready. [0003] The above extraction methods cannot fully extract the acti...

AI Technical Summary

Problems solved by technology

[0003] The above extraction methods cannot fully extract the active ingredients, and the bioavailability is low, which affects the efficacy of the drug and directly affects the therapeutic effect. The patient takes a large dose, which is not suitable for quantification, and there are deficiencies in high requirements for storage and transportation conditions.

[0004] In addition, the raw material prescription contains water pinellia, which has the effect of drying dampness, resolving phlegm and relieving cough, but water pinellia is slightly poisonous.

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