Multi-channel electrode sensor for detecting ovarian cancer markers
An electrode sensor and marker technology, which is applied in the fields of biosensing and tumor detection, can solve the problems of low specificity and sensitivity of enzyme-linked immunosorbent assay, radioactive radiation of radioimmunization method, and complicated operation of enzyme-linked immunosorbent method, etc. Integrated, low sample consumption, low cost effect
Active Publication Date: 2014-03-19
UNIV OF JINAN
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[0003] At present, methods for determining ovarian cancer markers include radioimmunoassay, enzyme-linked immunoassay, and gold standard method. Although these methods have different advantages, they still have shortcomings. For example, radioimmunoassay has problems such as radioactive radiation and pollution. The immunoassay has the disadvantages of complex operation, high equipment requirements, and the need for specialized operators, while the gold standard method has the disadvantages of low specificity and sensitivity compared with the enzyme-linked immunoassay
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[0024] The present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments, but not as a limitation of the present invention.
[0025] Such as figure 1 As shown, the multi-channel electrode sensor for detecting ovarian cancer markers of the present invention includes a substrate 1, an electrolytic cell region 2, a working electrode 3, a reference electrode 4 and an auxiliary electrode 5; the substrate 1 is a polyester film Rectangular substrate. The electrolytic cell area 2 is arranged on the substrate 1, and the shape of the electrolytic cell area 2 in this embodiment is circular. The working electrode 3, the reference electrode 4 and the auxiliary electrode 5 are respectively arranged in the electrolytic cell area 2, and are connected to the detection circuit of the multi-channel electrochemical workstation through the electrode lead wires 6 which are insulated from each other (the detection circuit of the m...
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The invention discloses a multi-channel electrode sensor for detecting ovarian cancer markers. The multi-channel electrode sensor comprises a substrate, an electrolytic tank region, four working electrodes, a reference electrode and an auxiliary electrode, wherein the electrolytic tank region is arranged on the substrate, and the working electrodes, the reference electrode and the auxiliary electrode are respectively arranged in the electrolytic tank region and are respectively connected with a multi-channel electrochemical working station detection circuit through mutually isolated electrode outgoing lines. The multi-channel electrode sensor for detecting the ovarian cancer markers has the advantages of convenience in manufacture, low cost, convenience in carrying, and easiness in minimization and integration, can simultaneously detect of four markers, is more convenient and rapid, is good in synchronization, is capable of reducing measurement errors, is remarkably increased in detection efficiency, and has important guiding significance for diagnosing, classifying and prognosing the tumor.
Description
technical field [0001] The invention relates to an electrode sensor, in particular to a multi-channel electrode sensor for simultaneously detecting four ovarian cancer markers, and belongs to the technical field of biological sensing and tumor detection. Background technique [0002] Ovarian cancer is one of the most common tumors in female reproductive organs, ranking third in incidence after cervical cancer and uterine body cancer. However, the number of deaths due to ovarian cancer ranks first in all types of gynecological tumors, posing a serious threat to women's lives. Due to the lack of specificity and sensitivity of the early symptoms of ovarian cancer, the early diagnosis rate is not high. The discovery and application of tumor markers is one of the commonly used methods for clinical detection of tumors, and is used for follow-up of tumors and observation of treatment effects. Simultaneous detection of mucin antigen CA12-5, alpha-fetoprotein AFP, human chorionic g...
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IPC IPC(8): G01N27/48
Inventor 吴丹魏琴马洪敏杜斌李玉阳
Owner UNIV OF JINAN