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Novel cordyceps sinensis capsule and preparation method thereof

A technology of Cordyceps sinensis and capsules, which is applied in the field of Cordyceps sinensis capsules and its preparation, can solve the problems of reduced fluidity of powders, and achieve the effects of improving compliance, reducing the number of capsules taken, and being easy to dissolve

Active Publication Date: 2014-09-17
中卫国健医药(江苏)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, once it is made into ultrafine powder, the fluidity of the powder will be greatly reduced, so if you want to achieve mass production and improve production efficiency, you must make the powder into granules

Method used

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  • Novel cordyceps sinensis capsule and preparation method thereof
  • Novel cordyceps sinensis capsule and preparation method thereof

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preparation example Construction

[0025] A preparation method of novel Cordyceps sinensis capsule, comprising the following steps:

[0026] Step 1: the natural Cordyceps sinensis and the Cordyceps sinensis fermented mycelium are respectively broken into superfine powders with an ultrafine pulverizer to make more than 1000 mesh; wherein the mass ratio of the Cordyceps fermented mycelium superfine powder to the natural Cordyceps sinensis superfine powder is 5: 1~20:1;

[0027] Step 2: Mix the superfine powder of fermented mycelium of Cordyceps sinensis with fillers and high-efficiency disintegrants, add binders until a soft material that is agglomerated and loose when touched is obtained, and granules are made into granules by extrusion granulator, and The prepared granules are dried; wherein the mass ratio of filler to Cordyceps fermented mycelium superfine powder is 1:2~1:8, and the mass ratio of high-efficiency disintegrating agent to Cordyceps sinensis fermented mycelium superfine powder is 1: 20~1:80; the ...

Embodiment 1

[0032] Embodiment 1 A kind of preparation method of Cordyceps sinensis capsule, comprises the following steps:

[0033] Step 1: The natural Cordyceps sinensis and the fermented mycelium of Cordyceps sinensis are respectively subjected to wall-breaking treatment with an ultrafine pulverizer to produce ultrafine powders with a mesh size of more than 1000;

[0034] Step 2: Take 5kg of Cordyceps sinensis fermented mycelium superfine powder, 2.5kg of starch, 0.25kg of sodium carboxymethyl starch, add 80% ethanol until the soft material is obtained into agglomerates and disperses when touched, and then through the extrusion granulation mechanism into 50-mesh granules, and dry the granules at 60°C;

[0035] Step 3: Mix the granules obtained in step 2 with 1 kg of natural Cordyceps superfine powder, 1 kg of mannitol, and 0.2 kg of sodium carboxymethyl starch, and add 80% ethanol until the mixture of natural Cordyceps superfine powder, mannitol and high-efficiency disintegrating agent ...

Embodiment 2

[0038] Embodiment 2 A kind of preparation method of Cordyceps sinensis capsule, comprises the following steps:

[0039] Step 1: The natural Cordyceps sinensis and the fermented mycelium of Cordyceps sinensis are respectively subjected to wall-breaking treatment with an ultrafine pulverizer to produce ultrafine powders with a mesh size of more than 1000;

[0040] Step 2: Take 8kg of Cordyceps sinensis fermented mycelium superfine powder, 1.6kg of lactose, 0.16kg of low-substituted hydroxypropyl cellulose, etc., add 60% ethanol until a soft material that is agglomerated and loose when touched is obtained, and squeezed The granulator makes 50-mesh granules, and the granules are dried at 70°C;

[0041]Step 3: Mix the granules obtained in Step 2 with 0.8kg of natural Cordyceps superfine powder, 1.6kg of mannitol, 0.1kg of low-substituted hydroxypropyl cellulose, etc., and add 60% ethanol until the natural Cordyceps superfine powder, mannitol and high-efficiency disintegration The ...

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Abstract

The invention provides a cordyceps sinensis capsule with stronger effect and more stable characters and a preparation method thereof. The cordyceps sinensis capsule provided by the invention comprises granule content and a capsule shell, wherein the granule content comprises a granule kernel and a granule shell, the granule kernel is made by adding a binding agent into a cordyceps sinensis fermentation mycelium, a filler and a high-efficiency disintegrating agent, extruding, contracting and pelletizing; and the granule shell is formed by adding the binding agent into cordyceps sinensis, mannitol and the high-efficiency disintegrating agent and coating mixture at the periphery of the granule kernel by secondary pelletizing. The cordyceps sinensis capsule provided by the invention has the obvious advantages that an original two-step pelletizing method is adopted, firstly the granule kernel containing cordyceps sinensis fermentation mycelium ultrafine powder is prepared, and then natural cordyceps sinensis ultrafine powder and mannitol are coated at the periphery of the granule kernel by adopting secondary pelletizing, so that the granule shell is formed; and natural effective ingredients and mannitol can be dissolved more easily, absorption is promoted, and pharmaceutical effect is played.

Description

technical field [0001] The invention belongs to the field of medicine or health product production, and relates to a Cordyceps sinensis capsule with stronger efficacy and more stable properties and a preparation method thereof. Background technique [0002] Natural Cordyceps sinensis is a complex of the subseapotta and larva corpses of the ergot fungus Cordyceps sinensis parasitizing on the larvae of bat moths. It is a traditional precious and nourishing Chinese herbal medicine; The varieties obtained by liquid fermentation culture, the artificially cultivated Cordyceps sinensis mycelium are easy to obtain, and the price is relatively low. Both have various functions such as regulating immune system function, anti-tumor, anti-fatigue, etc. The main active ingredients are: cordycepic acid, cordycepin, amino acid, cordyceps polysaccharide, alkaloid, protein, fat, vitamin B1, B2, and minerals Wait. [0003] Cordyceps products currently on the market mainly include tablets, pi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A23L33/00
Inventor 张立民王巧凤吴健秦德绅吉伟军吴吉洋
Owner 中卫国健医药(江苏)有限公司